Details
- scope
- Treatment-refractory OCD patients (31 studies, 116 subjects, multiple targets)
- claim_text
- Across 31 studies and 116 patients, deep brain stimulation produced a 45.1% reduction in Y-BOCS and a 60.0% responder rate in treatment-resistant OCD.
- section_id
- section_14
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- effect_size
- Y-BOCS reduction 45.1%; responder rate 60.0%
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-14
- source_kind
- review_finding
- source_path
- evidence/section_14_evidence_package.json
- source_span
- Conclusions Our analysis confirms that DBS constitutes a valid alternative to lesional surgery for severe, therapy-refractory OCD patients.
- study_system
- Treatment-refractory OCD patients (31 studies, 116 subjects, multiple targets)
- section_title
- Loop Dysfunction in Neurological and Psychiatric Disease
- evidence_summary
- Fixed and random-effects meta-analysis (1999–Jan 2014) of Y-BOCS pre/post-DBS changes across striatal, STN, and inferior thalamic peduncle targets.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-14
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 116, "doi": "10.1371/journal.pone.0133591", "claim": "Across 31 studies and 116 patients, deep brain stimulation produced a 45.1% reduction in Y-BOCS and a 60.0% responder rate in treatment-resistant OCD.", "cite_key": "Alonso2015", "evidence": "Fixed and random-effects meta-analysis (1999–Jan 2014) of Y-BOCS pre/post-DBS changes across striatal, STN, and inferior thalamic peduncle targets.", "effect_size": "Y-BOCS reduction 45.1%; responder rate 60.0%", "text_access": "fulltext", "study_system": "Treatment-refractory OCD patients (31 studies, 116 subjects, multiple targets)", "source_cluster_id": "cluster_13", "replication_status": "independently_replicated", "claim_source_sentence": "Conclusions\nOur analysis confirms that DBS constitutes a valid alternative to lesional surgery for severe,\ntherapy-refractory OCD patients.", "replication_evidence_dois": [ "10.1038/s41380-020-00933-x", "10.2174/1570159x17666190409142555" ], "effect_size_source_sentence": "Responders to DBS reported a significantly older age at onset of OCD\nthan non-responding patients (responders 17.1 years ± 7.9 vs non-responders 13.7 years ± 6.9,\nt = -2.0, df = 67.1, p = 0.04, 95% CI = -6.7 to -0.03)." }- source_refs
[ "paper:paper-f79fc7090a43" ]
- evidence_refs
[ { "ref": "paper:paper-f79fc7090a43" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }