Version history

{
  "scope": "Treatment-refractory OCD patients (31 studies, 116 subjects, multiple targets)",
  "claim_text": "Across 31 studies and 116 patients, deep brain stimulation produced a 45.1% reduction in Y-BOCS and a 60.0% responder rate in treatment-resistant OCD.",
  "raw_fields": {
    "n": 116,
    "doi": "10.1371/journal.pone.0133591",
    "claim": "Across 31 studies and 116 patients, deep brain stimulation produced a 45.1% reduction in Y-BOCS and a 60.0% responder rate in treatment-resistant OCD.",
    "cite_key": "Alonso2015",
    "evidence": "Fixed and random-effects meta-analysis (1999–Jan 2014) of Y-BOCS pre/post-DBS changes across striatal, STN, and inferior thalamic peduncle targets.",
    "effect_size": "Y-BOCS reduction 45.1%; responder rate 60.0%",
    "text_access": "fulltext",
    "study_system": "Treatment-refractory OCD patients (31 studies, 116 subjects, multiple targets)",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Conclusions\nOur analysis confirms that DBS constitutes a valid alternative to lesional surgery for severe,\ntherapy-refractory OCD patients.",
    "replication_evidence_dois": [
      "10.1038/s41380-020-00933-x",
      "10.2174/1570159x17666190409142555"
    ],
    "effect_size_source_sentence": "Responders to DBS reported a significantly older age at onset of OCD\nthan non-responding patients (responders 17.1 years ± 7.9 vs non-responders 13.7 years ± 6.9,\nt = -2.0, df = 67.1, p = 0.04, 95% CI = -6.7 to -0.03)."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": "Y-BOCS reduction 45.1%; responder rate 60.0%",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-f79fc7090a43"
  ],
  "source_span": "Conclusions Our analysis confirms that DBS constitutes a valid alternative to lesional surgery for severe, therapy-refractory OCD patients.",
  "study_system": "Treatment-refractory OCD patients (31 studies, 116 subjects, multiple targets)",
  "evidence_refs": [
    {
      "ref": "paper:paper-f79fc7090a43"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Fixed and random-effects meta-analysis (1999–Jan 2014) of Y-BOCS pre/post-DBS changes across striatal, STN, and inferior thalamic peduncle targets.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}