- claim_text
Chronic two-photon imaging in mouse binocular V1 shows that L2/3 dendritic spines undergo substantial turnover and eye-specific remapping during the critical period; spine retention is strongly tied to calcium activity matching the soma's preferred visual stimulus, with Hebbian and heterosynaptic mechanisms accounting for the localized organization.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41467-025-60825-y",
"claim": "Chronic two-photon imaging in mouse binocular V1 shows that L2/3 dendritic spines undergo substantial turnover and eye-specific remapping during the critical period; spine retention is strongly tied to calcium activity matching the soma's preferred visual stimulus, with Hebbian and heterosynaptic mechanisms accounting for the localized organization.",
"cite_key": "Tsimring2025",
"evidence": "Chronic two-photon imaging of identified L2/3 somata + spines in mouse binocular V1 showed turnover and eye-specific remapping during the critical period; a single-neuron model implicates Hebbian + heterosynaptic plasticity in producing local clustering of retained spines.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "Mouse binocular V1 L2/3 pyramidal neurons (in vivo chronic two-photon, critical period)",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "Spine retention is strongly linked to their calcium activity, particularly in response to the soma's preferred visual stimulus.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-9361f12c3198"
]
- evidence_refs
[
{
"ref": "paper:paper-9361f12c3198"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
Chronic two-photon imaging of identified L2/3 somata + spines in mouse binocular V1 showed turnover and eye-specific remapping during the critical period; a single-neuron model implicates Hebbian + heterosynaptic plasticity in producing local clustering of retained spines.