Mouse primary motor cortex (M1) contains a circuit-level layer-4-equivalent pop…

Mouse primary motor cortex (M1) contains a circuit-level layer-4-equivalent population of excitatory neurons at the L3/L5A border that receives primary thalamocortical input (from VL and PO) and projects largely unidirectionally to L2/3 without strong long-range corticocortical input or output, paralleling sensory-cortex L4 circuit logic.

{
  "n": 0,
  "doi": "10.7554/elife.05422",
  "claim": "Mouse primary motor cortex (M1) contains a circuit-level layer-4-equivalent population of excitatory neurons at the L3/L5A border that receives primary thalamocortical input (from VL and PO) and projects largely unidirectionally to L2/3 without strong long-range corticocortical input or output, paralleling sensory-cortex L4 circuit logic.",
  "cite_key": "Yamawaki2014",
  "evidence": "LSPS, paired recording, retrograde tracing and channelrhodopsin-assisted circuit mapping of M1-L4 candidate neurons in mouse forelimb motor cortex.",
  "effect_size": "qualitative — M1-L4 neurons exhibit the four canonical S1-L4 connectivity hallmarks",
  "text_access": "fulltext",
  "study_system": "mouse forelimb primary motor cortex, L3/L5A border neurons",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "M1, despite lacking a cytoarchitecturally distinct granular layer, nevertheless contains the circuit-level equivalent of L4 in the form of a layer of excitatory neurons at the layer 3/5A border having the same basic synaptic circuit organization as L4 neurons in sensory cortex",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "These neurons received TC input not only from VL but also from PO. This contrasts with S1 barrels, where VPM and PO axons target L4 and L5A, respectively"
}

[
  "paper:paper-a29242ac688f"
]

M1, despite lacking a cytoarchitecturally distinct granular layer, nevertheless contains the circuit-level equivalent of L4 in the form of a layer of excitatory neurons at the layer 3/5A border having the same basic synaptic circuit organization as L4 neurons in sensory cortex

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