Version history

{
  "scope": "mouse forelimb primary motor cortex, L3/L5A border neurons",
  "claim_text": "Mouse primary motor cortex (M1) contains a circuit-level layer-4-equivalent population of excitatory neurons at the L3/L5A border that receives primary thalamocortical input (from VL and PO) and projects largely unidirectionally to L2/3 without strong long-range corticocortical input or output, paralleling sensory-cortex L4 circuit logic.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.05422",
    "claim": "Mouse primary motor cortex (M1) contains a circuit-level layer-4-equivalent population of excitatory neurons at the L3/L5A border that receives primary thalamocortical input (from VL and PO) and projects largely unidirectionally to L2/3 without strong long-range corticocortical input or output, paralleling sensory-cortex L4 circuit logic.",
    "cite_key": "Yamawaki2014",
    "evidence": "LSPS, paired recording, retrograde tracing and channelrhodopsin-assisted circuit mapping of M1-L4 candidate neurons in mouse forelimb motor cortex.",
    "effect_size": "qualitative — M1-L4 neurons exhibit the four canonical S1-L4 connectivity hallmarks",
    "text_access": "fulltext",
    "study_system": "mouse forelimb primary motor cortex, L3/L5A border neurons",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "M1, despite lacking a cytoarchitecturally distinct granular layer, nevertheless contains the circuit-level equivalent of L4 in the form of a layer of excitatory neurons at the layer 3/5A border having the same basic synaptic circuit organization as L4 neurons in sensory cortex",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "These neurons received TC input not only from VL but also from PO. This contrasts with S1 barrels, where VPM and PO axons target L4 and L5A, respectively"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — M1-L4 neurons exhibit the four canonical S1-L4 connectivity hallmarks",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-a29242ac688f"
  ],
  "source_span": "M1, despite lacking a cytoarchitecturally distinct granular layer, nevertheless contains the circuit-level equivalent of L4 in the form of a layer of excitatory neurons at the layer 3/5A border having the same basic synaptic circuit organization as L4 neurons in sensory cortex",
  "study_system": "mouse forelimb primary motor cortex, L3/L5A border neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-a29242ac688f"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "LSPS, paired recording, retrograde tracing and channelrhodopsin-assisted circuit mapping of M1-L4 candidate neurons in mouse forelimb motor cortex.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}