- claim_text
Postmitotic deletion of Dicer in mouse VIP+ interneurons concordantly disrupts intrinsic and synaptic properties of VIP cells and connected pyramidal neurons, then triggers progressive VIP+ interneuron loss with elevated cortical LFP power, demonstrating CGE-lineage-specific miRNA dependence.
- raw_fields
{
"n": 0,
"doi": "10.1093/cercor/bhz236",
"claim": "Postmitotic deletion of Dicer in mouse VIP+ interneurons concordantly disrupts intrinsic and synaptic properties of VIP cells and connected pyramidal neurons, then triggers progressive VIP+ interneuron loss with elevated cortical LFP power, demonstrating CGE-lineage-specific miRNA dependence.",
"title": null,
"cite_key": "Qiu2020",
"evidence": "Conditional VIP-Cre;Dicer mouse with electrophysiology, in vivo LFP and behavior.",
"effect_size": "qualitative — progressive VIP+ loss",
"text_access": "abstract_only",
"study_system": "mouse cortex (VIP-Cre;Dicer conditional)",
"_source_cluster": "cluster_02_development_lineage",
"replication_status": "replication_unknown",
"_source_cluster_index": 78,
"claim_source_sentence": "Here, we conditionally removed Dicer in postmitotic VIP+ interneurons to block miRNA biogenesis.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-e09b4f7909d5"
]
- evidence_refs
[
{
"ref": "paper:paper-e09b4f7909d5"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}