Mouse motor cortex contains pyramidal neurons in a thin zone at the L3/5A borde…

Mouse motor cortex contains pyramidal neurons in a thin zone at the L3/5A border that exhibit prototypical L4-like circuit features: thalamic excitatory input, largely unidirectional excitatory output to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs — challenging the classical view that M1 lacks layer 4.

{
  "n": null,
  "doi": "10.7554/elife.05422",
  "claim": "Mouse motor cortex contains pyramidal neurons in a thin zone at the L3/5A border that exhibit prototypical L4-like circuit features: thalamic excitatory input, largely unidirectional excitatory output to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs — challenging the classical view that M1 lacks layer 4.",
  "cite_key": "Yamawaki2014",
  "evidence": "Laminar Channelrhodopsin-2-Assisted Circuit Mapping (sCRACM) and paired recordings in mouse forelimb M1 slices.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse forelimb M1, L3/5A pyramidal neurons (M1-L4)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, largely unidirectional excitatory outputs to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-a29242ac688f"
]

we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, largely unidirectional excitatory outputs to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs.

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