Version history

{
  "scope": "mouse anterolateral motor cortex (ALM), male and female",
  "claim_text": "In mouse anterolateral motor cortex, thalamocortical inputs from VM thalamus selectively excite L5B PT neurons (via apical tuft synapses in L1) and L2/3 excitatory neurons but not L6 CT neurons, defining cell-type-specific E→E targeting.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.1333-18.2018",
    "claim": "In mouse anterolateral motor cortex, thalamocortical inputs from VM thalamus selectively excite L5B PT neurons (via apical tuft synapses in L1) and L2/3 excitatory neurons but not L6 CT neurons, defining cell-type-specific E→E targeting.",
    "cite_key": "Guo2018",
    "evidence": "Channelrhodopsin-assisted circuit mapping and electrophysiology from retrogradely labeled PT, CT, and L2/3 neurons in mouse ALM.",
    "effect_size": "qualitative selectivity: VM→PT and VM→L2/3 strong vs VM→CT absent",
    "text_access": "abstract_only",
    "study_system": "mouse anterolateral motor cortex (ALM), male and female",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM. These axons also strongly excited layer 2/3 neurons (which strongly excite PT neurons, as previously shown) but not VM-projecting corticothalamic (CT) neurons in layer 6.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1523/JNEUROSCI.4023-14.2015",
      "10.1523/ENEURO.0154-24.2024"
    ],
    "effect_size_source_sentence": "The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1."
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative selectivity: VM→PT and VM→L2/3 strong vs VM→CT absent",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:e0b74a67-34de-4660-b780-ff95451e6841"
  ],
  "source_span": "In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM. These axons also strongly excited layer 2/3 neurons (which strongly excite PT neurons, as previously shown) but not VM-projecting corticothalamic (CT) neurons in layer 6.",
  "study_system": "mouse anterolateral motor cortex (ALM), male and female",
  "evidence_refs": [
    {
      "ref": "paper:e0b74a67-34de-4660-b780-ff95451e6841"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Channelrhodopsin-assisted circuit mapping and electrophysiology from retrogradely labeled PT, CT, and L2/3 neurons in mouse ALM.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}