Version history

{
  "scope": "mouse cortex, double-fluorescence transgenic",
  "claim_text": "The 5HT3a-BAC EGFP transgenic mouse line specifically labels CGE-derived 5HT3aR+ cortical interneurons including all VIP-expressing populations, with no overlap detected with Nkx2-1-BAC-Cre tdRFP-labeled MGE-lineage cells — providing the foundational genetic validation that all VIP-expressing cortical interneurons are CGE-derived and 5HT3aR-positive.",
  "raw_fields": {
    "n": null,
    "doi": "10.1002/dneu.20853",
    "claim": "The 5HT3a-BAC EGFP transgenic mouse line specifically labels CGE-derived 5HT3aR+ cortical interneurons including all VIP-expressing populations, with no overlap detected with Nkx2-1-BAC-Cre tdRFP-labeled MGE-lineage cells — providing the foundational genetic validation that all VIP-expressing cortical interneurons are CGE-derived and 5HT3aR-positive.",
    "title": null,
    "cite_key": "Rudy2011",
    "evidence": "Combinatorial 5HT3a-BAC EGFP × Nkx2-1-BAC-Cre tdRFP transgenic crosses; immunohistochemistry/imaging of mouse cortex.",
    "effect_size": "Zero overlap between MGE-fate-mapped (Nkx2-1) and CGE-fate-mapped (5HT3aR-EGFP) populations",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "mouse cortex, double-fluorescence transgenic",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "review",
    "_source_cluster_index": 119,
    "claim_source_sentence": "One was by combining the Nkx2-1-BAC cre and the cre-dependent red R26R tdRFP reporter with 5HT3aR-BAC EGFP showing that there is no overlap between red and green cells.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.1869-10.2010"
    ],
    "effect_size_source_sentence": "One was by combining the Nkx2-1-BAC cre and the cre-dependent red R26R tdRFP reporter with 5HT3aR-BAC EGFP showing that there is no overlap between red and green cells."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "Zero overlap between MGE-fate-mapped (Nkx2-1) and CGE-fate-mapped (5HT3aR-EGFP) populations",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
  ],
  "source_span": "One was by combining the Nkx2-1-BAC cre and the cre-dependent red R26R tdRFP reporter with 5HT3aR-BAC EGFP showing that there is no overlap between red and green cells.",
  "study_system": "mouse cortex, double-fluorescence transgenic",
  "evidence_refs": [
    {
      "ref": "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Combinatorial 5HT3a-BAC EGFP × Nkx2-1-BAC-Cre tdRFP transgenic crosses; immunohistochemistry/imaging of mouse cortex.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "review",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}