- claim_text
The 5HT3a-BAC EGFP transgenic mouse line specifically labels CGE-derived 5HT3aR+ cortical interneurons including all VIP-expressing populations, with no overlap detected with Nkx2-1-BAC-Cre tdRFP-labeled MGE-lineage cells — providing the foundational genetic validation that all VIP-expressing cortical interneurons are CGE-derived and 5HT3aR-positive.
- raw_fields
{
"n": null,
"doi": "10.1002/dneu.20853",
"claim": "The 5HT3a-BAC EGFP transgenic mouse line specifically labels CGE-derived 5HT3aR+ cortical interneurons including all VIP-expressing populations, with no overlap detected with Nkx2-1-BAC-Cre tdRFP-labeled MGE-lineage cells — providing the foundational genetic validation that all VIP-expressing cortical interneurons are CGE-derived and 5HT3aR-positive.",
"title": null,
"cite_key": "Rudy2011",
"evidence": "Combinatorial 5HT3a-BAC EGFP × Nkx2-1-BAC-Cre tdRFP transgenic crosses; immunohistochemistry/imaging of mouse cortex.",
"effect_size": "Zero overlap between MGE-fate-mapped (Nkx2-1) and CGE-fate-mapped (5HT3aR-EGFP) populations",
"figure_data": [],
"text_access": "fulltext",
"study_system": "mouse cortex, double-fluorescence transgenic",
"_source_cluster": "cluster_02_development_lineage",
"replication_status": "review",
"_source_cluster_index": 119,
"claim_source_sentence": "One was by combining the Nkx2-1-BAC cre and the cre-dependent red R26R tdRFP reporter with 5HT3aR-BAC EGFP showing that there is no overlap between red and green cells.",
"replication_evidence_dois": [
"10.1523/jneurosci.1869-10.2010"
],
"effect_size_source_sentence": "One was by combining the Nkx2-1-BAC cre and the cre-dependent red R26R tdRFP reporter with 5HT3aR-BAC EGFP showing that there is no overlap between red and green cells."
}- source_refs
[
"paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
]
- evidence_refs
[
{
"ref": "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}