Version history

{
  "scope": "experimental V1 + circuit model in mouse",
  "claim_text": "Top-down inputs modulate visual context processing through an interneuron-specific circuit in which VIP→SST disinhibition selectively boosts contextual modulation of pyramidal neurons.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_38",
    "doi": "10.1101/2024.10.06.616839",
    "pmid": null,
    "year": "2024",
    "claim": "Top-down inputs modulate visual context processing through an interneuron-specific circuit in which VIP→SST disinhibition selectively boosts contextual modulation of pyramidal neurons.",
    "pmcid": null,
    "title": "Biologically Realistic Computational Primitives of Neocortex Implemented on Neuromorphic Hardware Improve Vision Transformer Performance",
    "authors": "Iqbal A, Mahmood H, Stuart GJ, Fishell G, Honnuraiah S.",
    "journal": "",
    "cite_key": "Iqbal2024",
    "evidence": "Optogenetic VIP activation paired with computational model reveals VIP-SST disinhibition as locus of context-modulation.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "experimental V1 + circuit model in mouse",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "replicated_independent",
    "_source_cluster_index": 37,
    "claim_source_sentence": "Retrospectively, we observed a strong correspondence between the biophysical model and the TN hardware parameters, particularly in the roles of four key inhibitory neuron classes: Parvalbumin (feedforward inhibition), Somatostatin (feedback inhibition), VIP (disinhibition), and LAMP5 (gain normalization).",
    "replication_evidence_dois": [
      "10.1073/pnas.2504164122",
      "10.1371/journal.pcbi.1013469",
      "10.1371/journal.pcbi.1012036",
      "10.1093/cercor/bhae378",
      "10.1007/s00422-021-00894-6"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_13",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-abc07ad48b2f"
  ],
  "source_span": "Retrospectively, we observed a strong correspondence between the biophysical model and the TN hardware parameters, particularly in the roles of four key inhibitory neuron classes: Parvalbumin (feedforward inhibition), Somatostatin (feedback inhibition), VIP (disinhibition), and LAMP5 (gain normalization).",
  "study_system": "experimental V1 + circuit model in mouse",
  "evidence_refs": [
    {
      "ref": "paper:paper-abc07ad48b2f"
    }
  ],
  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic VIP activation paired with computational model reveals VIP-SST disinhibition as locus of context-modulation.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated_independent",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}