Details
- scope
- experimental V1 + circuit model in mouse
- claim_text
- Top-down inputs modulate visual context processing through an interneuron-specific circuit in which VIP→SST disinhibition selectively boosts contextual modulation of pyramidal neurons.
- section_id
- section_13
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-13-conclusion
- source_kind
- review_finding
- source_path
- evidence/section_13_evidence_package.json
- study_system
- experimental V1 + circuit model in mouse
- section_title
- Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
- evidence_summary
- Optogenetic VIP activation paired with computational model reveals VIP-SST disinhibition as locus of context-modulation.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated_independent
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-13-conclusion
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- raw_fields
{ "n": null, "id": "cluster_11_finding_38", "doi": "10.1101/2024.10.06.616839", "pmid": null, "year": "2024", "claim": "Top-down inputs modulate visual context processing through an interneuron-specific circuit in which VIP→SST disinhibition selectively boosts contextual modulation of pyramidal neurons.", "pmcid": null, "title": "Biologically Realistic Computational Primitives of Neocortex Implemented on Neuromorphic Hardware Improve Vision Transformer Performance", "authors": "Iqbal A, Mahmood H, Stuart GJ, Fishell G, Honnuraiah S.", "journal": "", "cite_key": "Iqbal2024", "evidence": "Optogenetic VIP activation paired with computational model reveals VIP-SST disinhibition as locus of context-modulation.", "effect_size": null, "text_access": "abstract_only", "study_system": "experimental V1 + circuit model in mouse", "_source_cluster": "cluster_11_computational_models", "replication_status": "replicated_independent", "_source_cluster_index": 37, "claim_source_sentence": "Retrospectively, we observed a strong correspondence between the biophysical model and the TN hardware parameters, particularly in the roles of four key inhibitory neuron classes: Parvalbumin (feedforward inhibition), Somatostatin (feedback inhibition), VIP (disinhibition), and LAMP5 (gain normalization).", "replication_evidence_dois": [ "10.1073/pnas.2504164122", "10.1371/journal.pcbi.1013469", "10.1371/journal.pcbi.1012036", "10.1093/cercor/bhae378", "10.1007/s00422-021-00894-6" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-abc07ad48b2f" ]
- source_span
Retrospectively, we observed a strong correspondence between the biophysical model and the TN hardware parameters, particularly in the roles of four key inhibitory neuron classes: Parvalbumin (feedforward inhibition), Somatostatin (feedback inhibition), VIP (disinhibition), and LAMP5 (gain normalization).
- evidence_refs
[ { "ref": "paper:paper-abc07ad48b2f" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }