Barrel-cortex axons projecting to mouse vibrissal motor cortex preferentially t…

Barrel-cortex axons projecting to mouse vibrissal motor cortex preferentially target upper-layer (L2/3, L5A) pyramidal neurons, with strongest input onto vM1 cells projecting back to vS1; deep-layer vM1 neurons (L5B, L6) receive weak S1 input despite axon-dendrite geometric overlap.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2011.07.029",
  "claim": "Barrel-cortex axons projecting to mouse vibrissal motor cortex preferentially target upper-layer (L2/3, L5A) pyramidal neurons, with strongest input onto vM1 cells projecting back to vS1; deep-layer vM1 neurons (L5B, L6) receive weak S1 input despite axon-dendrite geometric overlap.",
  "cite_key": "Mao2011",
  "evidence": "Channelrhodopsin-2 + anterograde/retrograde labeling and sCRACM circuit mapping in mouse barrel cortex → motor cortex.",
  "effect_size": "Layer-specific S1→M1 input with strongest connection onto M1 L2/3 cortico-cortical (back-to-S1) neurons.",
  "text_access": "abstract_only",
  "study_system": "mouse vibrissal S1 → M1; CRACM circuit mapping with retrograde labeling",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Barrel cortex axons preferentially targeted upper layer (L2/3, L5A) neurons in motor cortex; input to neurons projecting back to barrel cortex was particularly strong. Barrel cortex input to deeper layers (L5B, L6) of motor cortex, including neurons projecting to the brainstem, was weak, despite pronounced geometric overlap of dendrites with axons from barrel cortex.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.7554/eLife.66836"
  ],
  "effect_size_source_sentence": null
}

[
  "paper:fcc61ea6-0808-4982-bba8-392f7abe074f"
]

Barrel cortex axons preferentially targeted upper layer (L2/3, L5A) neurons in motor cortex; input to neurons projecting back to barrel cortex was particularly strong. Barrel cortex input to deeper layers (L5B, L6) of motor cortex, including neurons projecting to the brainstem, was weak, despite pronounced geometric overlap of dendrites with axons from barrel cortex.

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