Version history

{
  "scope": "rate model of cortical microcircuit with three interneuron subtypes",
  "claim_text": "A circuit mechanism modeled with PV, SST, and VIP interneurons enables independent modulation of excitatory and inhibitory firing rates via VIP-mediated disinhibition.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_138",
    "doi": "10.1073/pnas.2116895119",
    "pmid": "35925891",
    "year": "2022",
    "claim": "A circuit mechanism modeled with PV, SST, and VIP interneurons enables independent modulation of excitatory and inhibitory firing rates via VIP-mediated disinhibition.",
    "pmcid": "PMC9371725",
    "title": "A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation",
    "authors": "Richter LMA, Gjorgjieva J.",
    "journal": "Proceedings of the National Academy of Sciences",
    "cite_key": "Richter2022",
    "evidence": "Authors developed a rate model of cortical microcircuit with three interneuron subtypes consistent with the cluster's canonical VIP→SST→pyramidal disinhibitory architecture.",
    "vip_role": "gain_modulation",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "rate model of cortical microcircuit with three interneuron subtypes",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "replicated_independent",
    "_source_cluster_index": 137,
    "claim_source_sentence": "We find that with a single interneuron subtype (parvalbumin-expressing [PV]), excitatory and inhibitory firing rates can only be comodulated-increased or decreased together.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_13",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-0be3f798f821"
  ],
  "source_span": "We find that with a single interneuron subtype (parvalbumin-expressing [PV]), excitatory and inhibitory firing rates can only be comodulated-increased or decreased together.",
  "study_system": "rate model of cortical microcircuit with three interneuron subtypes",
  "evidence_refs": [
    {
      "ref": "paper:paper-0be3f798f821"
    }
  ],
  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Authors developed a rate model of cortical microcircuit with three interneuron subtypes consistent with the cluster's canonical VIP→SST→pyramidal disinhibitory architecture.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated_independent",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}