Details
- scope
- rate model of cortical microcircuit with three interneuron subtypes
- claim_text
- A circuit mechanism modeled with PV, SST, and VIP interneurons enables independent modulation of excitatory and inhibitory firing rates via VIP-mediated disinhibition.
- section_id
- section_13
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-13-conclusion
- source_kind
- review_finding
- source_path
- evidence/section_13_evidence_package.json
- source_span
- We find that with a single interneuron subtype (parvalbumin-expressing [PV]), excitatory and inhibitory firing rates can only be comodulated-increased or decreased together.
- study_system
- rate model of cortical microcircuit with three interneuron subtypes
- section_title
- Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
- evidence_summary
- Authors developed a rate model of cortical microcircuit with three interneuron subtypes consistent with the cluster's canonical VIP→SST→pyramidal disinhibitory architecture.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated_independent
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-13-conclusion
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
- raw_fields
{ "n": null, "id": "cluster_11_finding_138", "doi": "10.1073/pnas.2116895119", "pmid": "35925891", "year": "2022", "claim": "A circuit mechanism modeled with PV, SST, and VIP interneurons enables independent modulation of excitatory and inhibitory firing rates via VIP-mediated disinhibition.", "pmcid": "PMC9371725", "title": "A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation", "authors": "Richter LMA, Gjorgjieva J.", "journal": "Proceedings of the National Academy of Sciences", "cite_key": "Richter2022", "evidence": "Authors developed a rate model of cortical microcircuit with three interneuron subtypes consistent with the cluster's canonical VIP→SST→pyramidal disinhibitory architecture.", "vip_role": "gain_modulation", "effect_size": null, "text_access": "fulltext", "study_system": "rate model of cortical microcircuit with three interneuron subtypes", "_source_cluster": "cluster_11_computational_models", "replication_status": "replicated_independent", "_source_cluster_index": 137, "claim_source_sentence": "We find that with a single interneuron subtype (parvalbumin-expressing [PV]), excitatory and inhibitory firing rates can only be comodulated-increased or decreased together.", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-0be3f798f821" ]
- evidence_refs
[ { "ref": "paper:paper-0be3f798f821" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }