Version history

{
  "scope": "mouse MD–mPFC (DNMS T-maze working memory)",
  "claim_text": "MD-to-mPFC inputs are required to sustain delay-period prefrontal activity that supports spatial working memory maintenance, and the same delay-tuned mPFC neurons depend on MD but not hippocampal input.",
  "raw_fields": {
    "n": 891,
    "doi": "10.1038/nn.4568",
    "claim": "MD-to-mPFC inputs are required to sustain delay-period prefrontal activity that supports spatial working memory maintenance, and the same delay-tuned mPFC neurons depend on MD but not hippocampal input.",
    "cite_key": "Bolkan2017",
    "evidence": "Pathway-specific optogenetic inhibition and multi-region recordings during a delayed non-match-to-sample T-maze task in mice.",
    "effect_size": "266/891 mPFC neurons elevated during delay; MD-to-mPFC delay inhibition reduced performance from ~75% to ~67% correct",
    "text_access": "fulltext",
    "study_system": "mouse MD–mPFC (DNMS T-maze working memory)",
    "source_cluster_id": "cluster_05",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "These findings indicate a role for MD in sustaining prefrontal activity during working memory maintenance.",
    "replication_evidence_dois": [
      "10.1038/nature22324",
      "10.1038/nature22073"
    ],
    "effect_size_source_sentence": "Consistent with this, we found a subset of mPFC neurons (266/891) that exhibited significant elevation in spiking during the delay relative to the inter trial interval (ITI), where behavioral conditions were equivalent yet mice were not required to maintain task-relevant information across a delay."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "effect_size": "266/891 mPFC neurons elevated during delay; MD-to-mPFC delay inhibition reduced performance from ~75% to ~67% correct",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-3ec6d1461090"
  ],
  "source_span": "These findings indicate a role for MD in sustaining prefrontal activity during working memory maintenance.",
  "study_system": "mouse MD–mPFC (DNMS T-maze working memory)",
  "evidence_refs": [
    {
      "ref": "paper:paper-3ec6d1461090"
    }
  ],
  "section_title": "Thalamic Feedback: Closing the Loop",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Pathway-specific optogenetic inhibition and multi-region recordings during a delayed non-match-to-sample T-maze task in mice.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}