MD-to-mPFC inputs are required to sustain delay-period prefrontal activity that…

{
  "n": 891,
  "doi": "10.1038/nn.4568",
  "claim": "MD-to-mPFC inputs are required to sustain delay-period prefrontal activity that supports spatial working memory maintenance, and the same delay-tuned mPFC neurons depend on MD but not hippocampal input.",
  "cite_key": "Bolkan2017",
  "evidence": "Pathway-specific optogenetic inhibition and multi-region recordings during a delayed non-match-to-sample T-maze task in mice.",
  "effect_size": "266/891 mPFC neurons elevated during delay; MD-to-mPFC delay inhibition reduced performance from ~75% to ~67% correct",
  "text_access": "fulltext",
  "study_system": "mouse MD–mPFC (DNMS T-maze working memory)",
  "source_cluster_id": "cluster_05",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "These findings indicate a role for MD in sustaining prefrontal activity during working memory maintenance.",
  "replication_evidence_dois": [
    "10.1038/nature22324",
    "10.1038/nature22073"
  ],
  "effect_size_source_sentence": "Consistent with this, we found a subset of mPFC neurons (266/891) that exhibited significant elevation in spiking during the delay relative to the inter trial interval (ITI), where behavioral conditions were equivalent yet mice were not required to maintain task-relevant information across a delay."
}

[
  "paper:paper-3ec6d1461090"
]

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  }
]

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