Version history

{
  "scope": "mouse BLA acute slices, VIP-IRES-cre × Ai14",
  "claim_text": "In mouse basolateral amygdala, VIP+ irregular-spiking interneurons have ~70% higher input resistance than CCK+/CB1+ basket cells (350 ± 28 MΩ vs 203 ± 28 MΩ, p<0.001) and lower rheobase (43 ± 5 pA vs 133 ± 17 pA), with no difference in AP threshold, identifying high R_in / low rheobase as a robust feature of VIP-IS cells.",
  "raw_fields": {
    "n": 30,
    "doi": "10.1523/jneurosci.2063-17.2018",
    "claim": "In mouse basolateral amygdala, VIP+ irregular-spiking interneurons have ~70% higher input resistance than CCK+/CB1+ basket cells (350 ± 28 MΩ vs 203 ± 28 MΩ, p<0.001) and lower rheobase (43 ± 5 pA vs 133 ± 17 pA), with no difference in AP threshold, identifying high R_in / low rheobase as a robust feature of VIP-IS cells.",
    "title": null,
    "cite_key": "Rhomberg2018",
    "evidence": "VIP-IRES-cre × Ai14 mouse, BLA acute slices, whole-cell patch-clamp, n=30 IS-INs vs n=13 CCK+/CB1+ basket cells",
    "effect_size": "R_in: 350.30 ± 28.26 MΩ (n=30) vs 203.42 ± 27.75 MΩ (n=13), p<0.001; rheobase: 43.43 ± 4.80 pA (n=33) vs 133.13 ± 16.75 pA (n=16), p<0.001",
    "text_access": "fulltext",
    "study_system": "mouse BLA acute slices, VIP-IRES-cre × Ai14",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 7,
    "claim_source_sentence": "Single-cell properties of VIP+ IS-INs and CCK+/CB1 + basket cells IS-INs Basket cells t -Student p value Capacitance (pF) 46.92 ± 2.98 ( n = 30) 88.54 ± 8.16 ( n = 13) <0.001 a Input resistance (MΩ) 350.30 ± 28.26 ( n = 30) 203.42 ± 27.75 ( n = 13) <0.001 a Membrane time constant (ms) 14.79 ± 0.80 ( n = 30) 16.12 ± 1.42 ( n = 13) 0.426",
    "replication_evidence_dois": [
      "10.7554/elife.95412",
      "10.1523/jneurosci.2661-14.2015"
    ],
    "effect_size_source_sentence": "Single-cell properties of VIP+ IS-INs and CCK+/CB1 + basket cells IS-INs Basket cells t -Student p value Capacitance (pF) 46.92 ± 2.98 ( n = 30) 88.54 ± 8.16 ( n = 13) <0.001 a Input resistance (MΩ) 350.30 ± 28.26 ( n = 30) 203.42 ± 27.75 ( n = 13) <0.001 a Membrane time constant (ms) 14.79 ± 0.80 ( n = 30) 16.12 ± 1.42 ( n = 13) 0.426"
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "R_in: 350.30 ± 28.26 MΩ (n=30) vs 203.42 ± 27.75 MΩ (n=13), p<0.001; rheobase: 43.43 ± 4.80 pA (n=33) vs 133.13 ± 16.75 pA (n=16), p<0.001",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-51b86c64ced9"
  ],
  "source_span": "Single-cell properties of VIP+ IS-INs and CCK+/CB1 + basket cells IS-INs Basket cells t -Student p value Capacitance (pF) 46.92 ± 2.98 ( n = 30) 88.54 ± 8.16 ( n = 13) <0.001 a Input resistance (MΩ) 350.30 ± 28.26 ( n = 30) 203.42 ± 27.75 ( n = 13) <0.001 a Membrane time constant (ms) 14.79 ± 0.80 ( n = 30) 16.12 ± 1.42 ( n = 13) 0.426",
  "study_system": "mouse BLA acute slices, VIP-IRES-cre × Ai14",
  "evidence_refs": [
    {
      "ref": "paper:paper-51b86c64ced9"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "VIP-IRES-cre × Ai14 mouse, BLA acute slices, whole-cell patch-clamp, n=30 IS-INs vs n=13 CCK+/CB1+ basket cells",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}