- claim_text
In mouse basolateral amygdala, VIP+ irregular-spiking interneurons have ~70% higher input resistance than CCK+/CB1+ basket cells (350 ± 28 MΩ vs 203 ± 28 MΩ, p<0.001) and lower rheobase (43 ± 5 pA vs 133 ± 17 pA), with no difference in AP threshold, identifying high R_in / low rheobase as a robust feature of VIP-IS cells.
- raw_fields
{
"n": 30,
"doi": "10.1523/jneurosci.2063-17.2018",
"claim": "In mouse basolateral amygdala, VIP+ irregular-spiking interneurons have ~70% higher input resistance than CCK+/CB1+ basket cells (350 ± 28 MΩ vs 203 ± 28 MΩ, p<0.001) and lower rheobase (43 ± 5 pA vs 133 ± 17 pA), with no difference in AP threshold, identifying high R_in / low rheobase as a robust feature of VIP-IS cells.",
"title": null,
"cite_key": "Rhomberg2018",
"evidence": "VIP-IRES-cre × Ai14 mouse, BLA acute slices, whole-cell patch-clamp, n=30 IS-INs vs n=13 CCK+/CB1+ basket cells",
"effect_size": "R_in: 350.30 ± 28.26 MΩ (n=30) vs 203.42 ± 27.75 MΩ (n=13), p<0.001; rheobase: 43.43 ± 4.80 pA (n=33) vs 133.13 ± 16.75 pA (n=16), p<0.001",
"text_access": "fulltext",
"study_system": "mouse BLA acute slices, VIP-IRES-cre × Ai14",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replicated",
"_source_cluster_index": 7,
"claim_source_sentence": "Single-cell properties of VIP+ IS-INs and CCK+/CB1 + basket cells IS-INs Basket cells t -Student p value Capacitance (pF) 46.92 ± 2.98 ( n = 30) 88.54 ± 8.16 ( n = 13) <0.001 a Input resistance (MΩ) 350.30 ± 28.26 ( n = 30) 203.42 ± 27.75 ( n = 13) <0.001 a Membrane time constant (ms) 14.79 ± 0.80 ( n = 30) 16.12 ± 1.42 ( n = 13) 0.426",
"replication_evidence_dois": [
"10.7554/elife.95412",
"10.1523/jneurosci.2661-14.2015"
],
"effect_size_source_sentence": "Single-cell properties of VIP+ IS-INs and CCK+/CB1 + basket cells IS-INs Basket cells t -Student p value Capacitance (pF) 46.92 ± 2.98 ( n = 30) 88.54 ± 8.16 ( n = 13) <0.001 a Input resistance (MΩ) 350.30 ± 28.26 ( n = 30) 203.42 ± 27.75 ( n = 13) <0.001 a Membrane time constant (ms) 14.79 ± 0.80 ( n = 30) 16.12 ± 1.42 ( n = 13) 0.426"
}- source_refs
[
"paper:paper-51b86c64ced9"
]
- source_span
Single-cell properties of VIP+ IS-INs and CCK+/CB1 + basket cells IS-INs Basket cells t -Student p value Capacitance (pF) 46.92 ± 2.98 ( n = 30) 88.54 ± 8.16 ( n = 13) <0.001 a Input resistance (MΩ) 350.30 ± 28.26 ( n = 30) 203.42 ± 27.75 ( n = 13) <0.001 a Membrane time constant (ms) 14.79 ± 0.80 ( n = 30) 16.12 ± 1.42 ( n = 13) 0.426
- evidence_refs
[
{
"ref": "paper:paper-51b86c64ced9"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}