Version history

{
  "scope": "human MTG (snRNA-seq) vs. mouse cortex literature",
  "claim_text": "Human cortex maintains the cross-species pattern in which CGE-derived (ADARB2-branch) inhibitory neurons show greater diversity in superficial layers (L1–L3) and MGE-derived (LHX6-branch) interneurons show greater diversity in deeper layers (L4–L6) — confirming that the laminar bias of CGE/MGE-derived diversity is conserved between mouse and human cortex.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41586-019-1506-7",
    "claim": "Human cortex maintains the cross-species pattern in which CGE-derived (ADARB2-branch) inhibitory neurons show greater diversity in superficial layers (L1–L3) and MGE-derived (LHX6-branch) interneurons show greater diversity in deeper layers (L4–L6) — confirming that the laminar bias of CGE/MGE-derived diversity is conserved between mouse and human cortex.",
    "title": null,
    "cite_key": "Hodge2019",
    "evidence": "snRNA-seq of human MTG with layer-resolved nuclei dissection; cluster diversity (number of types) per layer compared to mouse cortex.",
    "effect_size": "ADARB2-branch diversity peaks in L1-L3; LHX6-branch diversity peaks in L4-L6 (conserved mouse↔human)",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "human MTG (snRNA-seq) vs. mouse cortex literature",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "primary",
    "_source_cluster_index": 109,
    "claim_source_sentence": "Consistent with mouse, the ADARB2 branch showed more diversity in L1-3 versus L4-6, and the opposite was true for the LHX6 branch ( Fig. 3 , Extended Data Fig. 10 ).",
    "replication_evidence_dois": [
      "10.1038/s41586-018-0654-5"
    ],
    "effect_size_source_sentence": "Consistent with mouse, the ADARB2 branch showed more diversity in L1-3 versus L4-6, and the opposite was true for the LHX6 branch ( Fig. 3 , Extended Data Fig. 10 )."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "ADARB2-branch diversity peaks in L1-L3; LHX6-branch diversity peaks in L4-L6 (conserved mouse↔human)",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-31435019"
  ],
  "source_span": "Consistent with mouse, the ADARB2 branch showed more diversity in L1-3 versus L4-6, and the opposite was true for the LHX6 branch ( Fig. 3 , Extended Data Fig. 10 ).",
  "study_system": "human MTG (snRNA-seq) vs. mouse cortex literature",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-31435019"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "snRNA-seq of human MTG with layer-resolved nuclei dissection; cluster diversity (number of types) per layer compared to mouse cortex.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "primary",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}