Human cortex maintains the cross-species pattern in which CGE-derived (ADARB2-b…

Human cortex maintains the cross-species pattern in which CGE-derived (ADARB2-branch) inhibitory neurons show greater diversity in superficial layers (L1–L3) and MGE-derived (LHX6-branch) interneurons show greater diversity in deeper layers (L4–L6) — confirming that the laminar bias of CGE/MGE-derived diversity is conserved between mouse and human cortex.

{
  "n": null,
  "doi": "10.1038/s41586-019-1506-7",
  "claim": "Human cortex maintains the cross-species pattern in which CGE-derived (ADARB2-branch) inhibitory neurons show greater diversity in superficial layers (L1–L3) and MGE-derived (LHX6-branch) interneurons show greater diversity in deeper layers (L4–L6) — confirming that the laminar bias of CGE/MGE-derived diversity is conserved between mouse and human cortex.",
  "title": null,
  "cite_key": "Hodge2019",
  "evidence": "snRNA-seq of human MTG with layer-resolved nuclei dissection; cluster diversity (number of types) per layer compared to mouse cortex.",
  "effect_size": "ADARB2-branch diversity peaks in L1-L3; LHX6-branch diversity peaks in L4-L6 (conserved mouse↔human)",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "human MTG (snRNA-seq) vs. mouse cortex literature",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "primary",
  "_source_cluster_index": 109,
  "claim_source_sentence": "Consistent with mouse, the ADARB2 branch showed more diversity in L1-3 versus L4-6, and the opposite was true for the LHX6 branch ( Fig. 3 , Extended Data Fig. 10 ).",
  "replication_evidence_dois": [
    "10.1038/s41586-018-0654-5"
  ],
  "effect_size_source_sentence": "Consistent with mouse, the ADARB2 branch showed more diversity in L1-3 versus L4-6, and the opposite was true for the LHX6 branch ( Fig. 3 , Extended Data Fig. 10 )."
}

[
  "paper:paper-pm-31435019"
]

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