Version history

{
  "scope": "mouse (Cre-driver IT/PT viral tracing)",
  "claim_text": "Comparing IT-type and PT-type layer 5 corticostriatal projections from sensory and motor cortex in Cre-driver mice showed somatotopic projections with decreasing topographic specificity from sensory→motor→frontal areas, and IT-type neurons had higher topographic stereotypy than PT-type neurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41467-018-05780-7",
    "claim": "Comparing IT-type and PT-type layer 5 corticostriatal projections from sensory and motor cortex in Cre-driver mice showed somatotopic projections with decreasing topographic specificity from sensory→motor→frontal areas, and IT-type neurons had higher topographic stereotypy than PT-type neurons.",
    "cite_key": "Hooks2018",
    "evidence": "AAV anterograde labeling from sensory and motor cortex in IT- and PT-Cre driver mouse lines, with quantitative comparison of striatal target overlap.",
    "effect_size": "IT > PT in topographic stereotypy of striatal targets; sensory > motor > frontal in topographic specificity (qualitative)",
    "text_access": "fulltext",
    "study_system": "mouse (Cre-driver IT/PT viral tracing)",
    "source_cluster_id": "cluster_03",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "IT-type neurons in sensory and motor areas target topographically organized domains of striatum and also overlap substantially with other cortical areas with which they are reciprocally connected.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Corticostriatal projections from sensory and motor cortex are somatotopic, with a decreasing topographic specificity as injection sites move from sensory to motor and frontal areas."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "effect_size": "IT > PT in topographic stereotypy of striatal targets; sensory > motor > frontal in topographic specificity (qualitative)",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-470beb0644b3"
  ],
  "source_span": "IT-type neurons in sensory and motor areas target topographically organized domains of striatum and also overlap substantially with other cortical areas with which they are reciprocally connected.",
  "study_system": "mouse (Cre-driver IT/PT viral tracing)",
  "evidence_refs": [
    {
      "ref": "paper:paper-470beb0644b3"
    }
  ],
  "section_title": "The Cortico-Striatal Interface: Topography, Cell Types, and Input Convergence",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "AAV anterograde labeling from sensory and motor cortex in IT- and PT-Cre driver mouse lines, with quantitative comparison of striatal target overlap.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}