Comparing IT-type and PT-type layer 5 corticostriatal projections from sensory…

Comparing IT-type and PT-type layer 5 corticostriatal projections from sensory and motor cortex in Cre-driver mice showed somatotopic projections with decreasing topographic specificity from sensory→motor→frontal areas, and IT-type neurons had higher topographic stereotypy than PT-type neurons.

{
  "n": null,
  "doi": "10.1038/s41467-018-05780-7",
  "claim": "Comparing IT-type and PT-type layer 5 corticostriatal projections from sensory and motor cortex in Cre-driver mice showed somatotopic projections with decreasing topographic specificity from sensory→motor→frontal areas, and IT-type neurons had higher topographic stereotypy than PT-type neurons.",
  "cite_key": "Hooks2018",
  "evidence": "AAV anterograde labeling from sensory and motor cortex in IT- and PT-Cre driver mouse lines, with quantitative comparison of striatal target overlap.",
  "effect_size": "IT > PT in topographic stereotypy of striatal targets; sensory > motor > frontal in topographic specificity (qualitative)",
  "text_access": "fulltext",
  "study_system": "mouse (Cre-driver IT/PT viral tracing)",
  "source_cluster_id": "cluster_03",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "IT-type neurons in sensory and motor areas target topographically organized domains of striatum and also overlap substantially with other cortical areas with which they are reciprocally connected.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Corticostriatal projections from sensory and motor cortex are somatotopic, with a decreasing topographic specificity as injection sites move from sensory to motor and frontal areas."
}

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]

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