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- Live5/17/2026, 4:35:28 PM
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{ "scope": "rat frontal cortex L5, retrogradely labeled CCS and CPn pyramidal neurons", "claim_text": "In rat frontal cortex L5, paired recordings show corticopontine (CPn/PT-like) pyramidal pairs exhibit greater reciprocal connectivity, stronger unitary EPSCs and more paired-pulse facilitation than crossed-corticostriatal (CCS/IT-like) pairs, defining projection-target-specific E→E subnetworks within the same layer.", "raw_fields": { "n": 0, "doi": "10.1523/jneurosci.0772-11.2011", "claim": "In rat frontal cortex L5, paired recordings show corticopontine (CPn/PT-like) pyramidal pairs exhibit greater reciprocal connectivity, stronger unitary EPSCs and more paired-pulse facilitation than crossed-corticostriatal (CCS/IT-like) pairs, defining projection-target-specific E→E subnetworks within the same layer.", "cite_key": "Morishima2011", "evidence": "Paired patch-clamp recordings and quantitative morphological analysis of retrogradely labeled CCS and CPn L5 pyramidal neurons in rat frontal cortex.", "effect_size": "qualitative — stronger CPn↔CPn reciprocal connectivity and unitary EPSCs vs CCS↔CCS", "text_access": "abstract_only", "study_system": "rat frontal cortex L5, retrogradely labeled CCS and CPn pyramidal neurons", "argument_role": "supporting", "replication_status": "independently_replicated", "claim_source_sentence": "Although CPn/CPn and CCS/CCS pairs had similar connection probabilities, CPn/CPn pairs exhibited greater reciprocal connectivity, stronger unitary synaptic transmission, and more facilitation of paired-pulse responses.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [ "10.1523/JNEUROSCI.2810-11.2012", "10.1093/cercor/bhx276" ], "effect_size_source_sentence": "Although CPn/CPn and CCS/CCS pairs had similar connection probabilities, CPn/CPn pairs exhibited greater reciprocal connectivity, stronger unitary synaptic transmission, and more facilitation of paired-pulse responses." }, "section_id": "section_07", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json", "effect_size": "qualitative — stronger CPn↔CPn reciprocal connectivity and unitary EPSCs vs CCS↔CCS", "review_repo": "ComputationalReviewRecurrence", "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs", "source_kind": "review_finding", "source_path": "evidence/section_07_evidence_package.json", "source_refs": [ "paper:paper-25eedc47d144" ], "source_span": "Although CPn/CPn and CCS/CCS pairs had similar connection probabilities, CPn/CPn pairs exhibited greater reciprocal connectivity, stronger unitary synaptic transmission, and more facilitation of paired-pulse responses.", "study_system": "rat frontal cortex L5, retrogradely labeled CCS and CPn pyramidal neurons", "evidence_refs": [ { "ref": "paper:paper-25eedc47d144" } ], "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }, "evidence_summary": "Paired patch-clamp recordings and quantitative morphological analysis of retrogradely labeled CCS and CPn L5 pyramidal neurons in rat frontal cortex.", "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9", "replication_status": "independently_replicated", "review_package_ref": "analysis_bundle:ab-d9c479db9be9", "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json", "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }