Details

scope
rat frontal cortex L5, retrogradely labeled CCS and CPn pyramidal neurons
section_id
section_07
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json
effect_size
qualitative — stronger CPn↔CPn reciprocal connectivity and unitary EPSCs vs CCS↔CCS
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-07-celltype-motifs
source_kind
review_finding
source_path
evidence/section_07_evidence_package.json
source_span
Although CPn/CPn and CCS/CCS pairs had similar connection probabilities, CPn/CPn pairs exhibited greater reciprocal connectivity, stronger unitary synaptic transmission, and more facilitation of paired-pulse responses.
study_system
rat frontal cortex L5, retrogradely labeled CCS and CPn pyramidal neurons
section_title
7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity
evidence_summary
Paired patch-clamp recordings and quantitative morphological analysis of retrogradely labeled CCS and CPn L5 pyramidal neurons in rat frontal cortex.
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
independently_replicated
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-07-celltype-motifs
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
claim_text
In rat frontal cortex L5, paired recordings show corticopontine (CPn/PT-like) pyramidal pairs exhibit greater reciprocal connectivity, stronger unitary EPSCs and more paired-pulse facilitation than crossed-corticostriatal (CCS/IT-like) pairs, defining projection-target-specific E→E subnetworks within the same layer.
raw_fields
{
  "n": 0,
  "doi": "10.1523/jneurosci.0772-11.2011",
  "claim": "In rat frontal cortex L5, paired recordings show corticopontine (CPn/PT-like) pyramidal pairs exhibit greater reciprocal connectivity, stronger unitary EPSCs and more paired-pulse facilitation than crossed-corticostriatal (CCS/IT-like) pairs, defining projection-target-specific E→E subnetworks within the same layer.",
  "cite_key": "Morishima2011",
  "evidence": "Paired patch-clamp recordings and quantitative morphological analysis of retrogradely labeled CCS and CPn L5 pyramidal neurons in rat frontal cortex.",
  "effect_size": "qualitative — stronger CPn↔CPn reciprocal connectivity and unitary EPSCs vs CCS↔CCS",
  "text_access": "abstract_only",
  "study_system": "rat frontal cortex L5, retrogradely labeled CCS and CPn pyramidal neurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Although CPn/CPn and CCS/CCS pairs had similar connection probabilities, CPn/CPn pairs exhibited greater reciprocal connectivity, stronger unitary synaptic transmission, and more facilitation of paired-pulse responses.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1523/JNEUROSCI.2810-11.2012",
    "10.1093/cercor/bhx276"
  ],
  "effect_size_source_sentence": "Although CPn/CPn and CCS/CCS pairs had similar connection probabilities, CPn/CPn pairs exhibited greater reciprocal connectivity, stronger unitary synaptic transmission, and more facilitation of paired-pulse responses."
}
source_refs
[
  "paper:paper-25eedc47d144"
]
evidence_refs
[
  {
    "ref": "paper:paper-25eedc47d144"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

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