Multi-probe Neuropixels recordings across loops connected to mouse ALM in a mem…

Multi-probe Neuropixels recordings across loops connected to mouse ALM in a memory-guided directional licking task show that choice coding is concentrated in ALM and ALM-recipient subcortical areas (and is ALM-dependent), choice signals arise first in ALM and midbrain before spreading to thalamus and other regions, and at movement initiation choice-selective activity collapses across the brain and is replaced by action-driving patterns.

{
  "n": 0,
  "doi": "10.1016/j.cell.2023.12.035",
  "claim": "Multi-probe Neuropixels recordings across loops connected to mouse ALM in a memory-guided directional licking task show that choice coding is concentrated in ALM and ALM-recipient subcortical areas (and is ALM-dependent), choice signals arise first in ALM and midbrain before spreading to thalamus and other regions, and at movement initiation choice-selective activity collapses across the brain and is replaced by action-driving patterns.",
  "cite_key": "Chen2024",
  "evidence": "Choice coding was concentrated in the ALM and subcortical areas receiving input from the ALM in an ALM-dependent manner. Diverse orofacial movements were encoded in the hindbrain; midbrain; and, to a lesser extent, forebrain. At movement initiation, choice-selective activity collapsed across the brain, followed by new activity patterns driving specific actions.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse ALM-connected loops; multi-probe Neuropixels recordings in a memory-guided directional licking task",
  "argument_role": "supporting",
  "replication_status": "single_lab",
  "claim_source_sentence": "Choice signals were first detected in the ALM and the midbrain, followed by the thalamus and other brain areas.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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Choice coding was concentrated in the ALM and subcortical areas receiving input from the ALM in an ALM-dependent manner. Diverse orofacial movements were encoded in the hindbrain; midbrain; and, to a lesser extent, forebrain. At movement initiation, choice-selective activity collapsed across the brain, followed by new activity patterns driving specific actions.