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- Live5/17/2026, 4:35:28 PM
2b56a51d10d5Content snapshot
{ "scope": "mouse ALM-connected loops; multi-probe Neuropixels recordings in a memory-guided directional licking task", "claim_text": "Multi-probe Neuropixels recordings across loops connected to mouse ALM in a memory-guided directional licking task show that choice coding is concentrated in ALM and ALM-recipient subcortical areas (and is ALM-dependent), choice signals arise first in ALM and midbrain before spreading to thalamus and other regions, and at movement initiation choice-selective activity collapses across the brain and is replaced by action-driving patterns.", "raw_fields": { "n": 0, "doi": "10.1016/j.cell.2023.12.035", "claim": "Multi-probe Neuropixels recordings across loops connected to mouse ALM in a memory-guided directional licking task show that choice coding is concentrated in ALM and ALM-recipient subcortical areas (and is ALM-dependent), choice signals arise first in ALM and midbrain before spreading to thalamus and other regions, and at movement initiation choice-selective activity collapses across the brain and is replaced by action-driving patterns.", "cite_key": "Chen2024", "evidence": "Choice coding was concentrated in the ALM and subcortical areas receiving input from the ALM in an ALM-dependent manner. Diverse orofacial movements were encoded in the hindbrain; midbrain; and, to a lesser extent, forebrain. At movement initiation, choice-selective activity collapsed across the brain, followed by new activity patterns driving specific actions.", "effect_size": "", "text_access": "abstract_only", "study_system": "mouse ALM-connected loops; multi-probe Neuropixels recordings in a memory-guided directional licking task", "argument_role": "supporting", "replication_status": "single_lab", "claim_source_sentence": "Choice signals were first detected in the ALM and the midbrain, followed by the thalamus and other brain areas.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": null }, "section_id": "section_10", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json", "effect_size": "", "review_repo": "ComputationalReviewRecurrence", "section_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity", "source_kind": "review_finding", "source_path": "evidence/section_10_evidence_package.json", "source_refs": [ "paper:c5e6a37d-7b06-4951-80e4-a50d24d476b4" ], "source_span": "Choice signals were first detected in the ALM and the midbrain, followed by the thalamus and other brain areas.", "study_system": "mouse ALM-connected loops; multi-probe Neuropixels recordings in a memory-guided directional licking task", "evidence_refs": [ { "ref": "paper:c5e6a37d-7b06-4951-80e4-a50d24d476b4" } ], "section_title": "10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }, "evidence_summary": "Choice coding was concentrated in the ALM and subcortical areas receiving input from the ALM in an ALM-dependent manner. Diverse orofacial movements were encoded in the hindbrain; midbrain; and, to a lesser extent, forebrain. At movement initiation, choice-selective activity collapsed across the brain, followed by new activity patterns driving specific actions.", "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9", "replication_status": "single_lab", "review_package_ref": "analysis_bundle:ab-d9c479db9be9", "source_artifact_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json", "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }