In mouse visual cortex, laminar patterns of axonal projections among ten interc…

In mouse visual cortex, laminar patterns of axonal projections among ten interconnected areas yield a well-ordered feedforward/feedback hierarchy when ranked by laminar projection asymmetry, while a substantial number of inter-area pathways are quantitatively non-hierarchical, supporting a mixed hierarchical/non-hierarchical organization.

{
  "n": 0,
  "doi": "10.1038/s41467-022-28035-y",
  "claim": "In mouse visual cortex, laminar patterns of axonal projections among ten interconnected areas yield a well-ordered feedforward/feedback hierarchy when ranked by laminar projection asymmetry, while a substantial number of inter-area pathways are quantitatively non-hierarchical, supporting a mixed hierarchical/non-hierarchical organization.",
  "cite_key": "DSouza2022",
  "evidence": "Bulk biotinylated dextran amine (BDA) anterograde injections into 10 mouse visual cortical areas (with paired BDA injections to identify laminar projection patterns), and quantitative regression on laminar projection density ratios to compute hierarchical level for each area-pair.",
  "effect_size": "Hierarchy across 10 visual areas plus identification of explicitly non-hierarchical 'lateral' connections",
  "text_access": "fulltext",
  "study_system": "mouse visual cortex, 10-area interareal projection network, anterograde tracing",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "To determine the layout of the mouse visual hierarchy, we have evaluated the laminar patterns formed by interareal axonal projections originating in each of ten areas.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1038/nn.3300",
    "10.1002/cne.70111"
  ],
  "effect_size_source_sentence": "Reciprocally connected pairs of areas exhibit feedforward/feedback relationships consistent with a hierarchical organization, and we identify previously uncharacterized non-hierarchical motifs that involve communication between areal pairs that do not exhibit conventional FF and FB relationships."
}

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Bulk biotinylated dextran amine (BDA) anterograde injections into 10 mouse visual cortical areas (with paired BDA injections to identify laminar projection patterns), and quantitative regression on laminar projection density ratios to compute hierarchical level for each area-pair.