- claim_text
Channelrhodopsin-2-assisted circuit mapping in mouse vibrissal motor cortex (vM1) shows each long-range excitatory input has a unique laminar profile: orbital cortex targets L6, secondary motor cortex (M2) targets L5B including pyramidal-tract neurons, anterior motor thalamus (VA/VL) targets L2/3 through L5B avoiding L6, while posterior sensory thalamus (POm) and somatosensory cortex target only upper layers — anatomy that defines the synaptic substrate for layered preparatory dynamics in motor cortex.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.4338-12.2013",
"claim": "Channelrhodopsin-2-assisted circuit mapping in mouse vibrissal motor cortex (vM1) shows each long-range excitatory input has a unique laminar profile: orbital cortex targets L6, secondary motor cortex (M2) targets L5B including pyramidal-tract neurons, anterior motor thalamus (VA/VL) targets L2/3 through L5B avoiding L6, while posterior sensory thalamus (POm) and somatosensory cortex target only upper layers — anatomy that defines the synaptic substrate for layered preparatory dynamics in motor cortex.",
"cite_key": "Hooks2013",
"evidence": "Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons. In contrast, thalamocortical inputs from anterior motor-related thalamic regions, including VA/VL, targeted neurons in L2/3 through L5B, but avoided L6. Inputs from posterior sensory-related thalamic areas, including POm, targeted neurons only in the upper layers.",
"effect_size": "",
"text_access": "abstract_only",
"study_system": "mouse vibrissal primary motor cortex layer-specific synaptic inputs; channelrhodopsin-2-assisted circuit mapping from multiple cortical and thalamic source regions",
"argument_role": "supporting",
"replication_status": "single_lab",
"claim_source_sentence": "Each projection innervated vM1 pyramidal neurons with a unique laminar profile.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
]
- evidence_refs
[
{
"ref": "paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
}
]- source_policy
{
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"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons. In contrast, thalamocortical inputs from anterior motor-related thalamic regions, including VA/VL, targeted neurons in L2/3 through L5B, but avoided L6. Inputs from posterior sensory-related thalamic areas, including POm, targeted neurons only in the upper layers.