Version history

{
  "scope": "mouse vibrissal primary motor cortex layer-specific synaptic inputs; channelrhodopsin-2-assisted circuit mapping from multiple cortical and thalamic source regions",
  "claim_text": "Channelrhodopsin-2-assisted circuit mapping in mouse vibrissal motor cortex (vM1) shows each long-range excitatory input has a unique laminar profile: orbital cortex targets L6, secondary motor cortex (M2) targets L5B including pyramidal-tract neurons, anterior motor thalamus (VA/VL) targets L2/3 through L5B avoiding L6, while posterior sensory thalamus (POm) and somatosensory cortex target only upper layers — anatomy that defines the synaptic substrate for layered preparatory dynamics in motor cortex.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.4338-12.2013",
    "claim": "Channelrhodopsin-2-assisted circuit mapping in mouse vibrissal motor cortex (vM1) shows each long-range excitatory input has a unique laminar profile: orbital cortex targets L6, secondary motor cortex (M2) targets L5B including pyramidal-tract neurons, anterior motor thalamus (VA/VL) targets L2/3 through L5B avoiding L6, while posterior sensory thalamus (POm) and somatosensory cortex target only upper layers — anatomy that defines the synaptic substrate for layered preparatory dynamics in motor cortex.",
    "cite_key": "Hooks2013",
    "evidence": "Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons. In contrast, thalamocortical inputs from anterior motor-related thalamic regions, including VA/VL, targeted neurons in L2/3 through L5B, but avoided L6. Inputs from posterior sensory-related thalamic areas, including POm, targeted neurons only in the upper layers.",
    "effect_size": "",
    "text_access": "abstract_only",
    "study_system": "mouse vibrissal primary motor cortex layer-specific synaptic inputs; channelrhodopsin-2-assisted circuit mapping from multiple cortical and thalamic source regions",
    "argument_role": "supporting",
    "replication_status": "single_lab",
    "claim_source_sentence": "Each projection innervated vM1 pyramidal neurons with a unique laminar profile.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "effect_size": "",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
  ],
  "source_span": "Each projection innervated vM1 pyramidal neurons with a unique laminar profile.",
  "study_system": "mouse vibrissal primary motor cortex layer-specific synaptic inputs; channelrhodopsin-2-assisted circuit mapping from multiple cortical and thalamic source regions",
  "evidence_refs": [
    {
      "ref": "paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
    }
  ],
  "section_title": "10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons. In contrast, thalamocortical inputs from anterior motor-related thalamic regions, including VA/VL, targeted neurons in L2/3 through L5B, but avoided L6. Inputs from posterior sensory-related thalamic areas, including POm, targeted neurons only in the upper layers.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}