Version history

{
  "scope": "mouse S1 L5 IT vs PT pyramidal cells; opto + retrograde",
  "claim_text": "In mouse S1, parallel cortico-cortical pathways from M1 onto L5 IT vs PT neurons have opposite short-term dynamics: M1→IT synapses depress while M1→PT synapses robustly facilitate, generating distinct burst-promoting responses in PT cells.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/eneuro.0154-24.2024",
    "claim": "In mouse S1, parallel cortico-cortical pathways from M1 onto L5 IT vs PT neurons have opposite short-term dynamics: M1→IT synapses depress while M1→PT synapses robustly facilitate, generating distinct burst-promoting responses in PT cells.",
    "cite_key": "Kim2024b",
    "evidence": "Optogenetic activation of M1 axons in S1 slices with paired-style recordings from retrogradely labeled IT and PT L5 neurons in mouse.",
    "effect_size": "Opposite short-term plasticity signs at M1→IT vs M1→PT inputs.",
    "text_access": "abstract_only",
    "study_system": "mouse S1 L5 IT vs PT pyramidal cells; opto + retrograde",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We found that M1 synapses onto IT cells displayed modest short-term depression, whereas synapses onto PT neurons showed robust short-term facilitation. Despite M1 inputs to IT cells depressing, their slower kinetics resulted in summation and a response that increased during short trains.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Opposite short-term plasticity signs at M1→IT vs M1→PT inputs.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-4f08ea59de5f"
  ],
  "source_span": "We found that M1 synapses onto IT cells displayed modest short-term depression, whereas synapses onto PT neurons showed robust short-term facilitation. Despite M1 inputs to IT cells depressing, their slower kinetics resulted in summation and a response that increased during short trains.",
  "study_system": "mouse S1 L5 IT vs PT pyramidal cells; opto + retrograde",
  "evidence_refs": [
    {
      "ref": "paper:paper-4f08ea59de5f"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Optogenetic activation of M1 axons in S1 slices with paired-style recordings from retrogradely labeled IT and PT L5 neurons in mouse.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}