Details

scope
mouse S1 L5 IT vs PT pyramidal cells; opto + retrograde
claim_text
In mouse S1, parallel cortico-cortical pathways from M1 onto L5 IT vs PT neurons have opposite short-term dynamics: M1→IT synapses depress while M1→PT synapses robustly facilitate, generating distinct burst-promoting responses in PT cells.
section_id
section_04
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
effect_size
Opposite short-term plasticity signs at M1→IT vs M1→PT inputs.
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-04-translaminar
source_kind
review_finding
source_path
evidence/section_04_evidence_package.json
study_system
mouse S1 L5 IT vs PT pyramidal cells; opto + retrograde
section_title
4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections
evidence_summary
Optogenetic activation of M1 axons in S1 slices with paired-style recordings from retrogradely labeled IT and PT L5 neurons in mouse.
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-04-translaminar
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
raw_fields
{
  "n": 0,
  "doi": "10.1523/eneuro.0154-24.2024",
  "claim": "In mouse S1, parallel cortico-cortical pathways from M1 onto L5 IT vs PT neurons have opposite short-term dynamics: M1→IT synapses depress while M1→PT synapses robustly facilitate, generating distinct burst-promoting responses in PT cells.",
  "cite_key": "Kim2024b",
  "evidence": "Optogenetic activation of M1 axons in S1 slices with paired-style recordings from retrogradely labeled IT and PT L5 neurons in mouse.",
  "effect_size": "Opposite short-term plasticity signs at M1→IT vs M1→PT inputs.",
  "text_access": "abstract_only",
  "study_system": "mouse S1 L5 IT vs PT pyramidal cells; opto + retrograde",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We found that M1 synapses onto IT cells displayed modest short-term depression, whereas synapses onto PT neurons showed robust short-term facilitation. Despite M1 inputs to IT cells depressing, their slower kinetics resulted in summation and a response that increased during short trains.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-4f08ea59de5f"
]
source_span
We found that M1 synapses onto IT cells displayed modest short-term depression, whereas synapses onto PT neurons showed robust short-term facilitation. Despite M1 inputs to IT cells depressing, their slower kinetics resulted in summation and a response that increased during short trains.
evidence_refs
[
  {
    "ref": "paper:paper-4f08ea59de5f"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

Voting as anonymous. Sign in to attribute your signals.

tokens

Replication

No replications yet

Discussion

Posting anonymously. Sign in for attribution.

No comments yet — be the first.