Version history

{
  "scope": "Awake mouse S1; L5 cell-class-specific transgenic mice; recordings and optogenetic manipulation of apical dendrites in PT vs IT L5 neurons during whisker-detection task",
  "claim_text": "Within mouse S1, apical-dendrite activation of subcortically projecting L5 pyramidal neurons (PT-type) almost exclusively accounts for tactile detection performance, while corticocortical L5 neurons contribute negligibly to the perceptual readout.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41593-020-0677-8",
    "claim": "Within mouse S1, apical-dendrite activation of subcortically projecting L5 pyramidal neurons (PT-type) almost exclusively accounts for tactile detection performance, while corticocortical L5 neurons contribute negligibly to the perceptual readout.",
    "cite_key": "Takahashi2020",
    "evidence": "Transgenic mouse lines selectively labelling subcortically-projecting vs cortico-cortically-projecting L5 pyramidal subclasses; recordings and manipulations of apical-dendrite activity during whisker-detection behavior.",
    "effect_size": "Subcortically-projecting L5 apical-dendrite activation determines detection; corticocortically-projecting L5 apical activation does not.",
    "text_access": "abstract_only",
    "study_system": "Awake mouse S1; L5 cell-class-specific transgenic mice; recordings and optogenetic manipulation of apical dendrites in PT vs IT L5 neurons during whisker-detection task",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "We found that the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli"
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Subcortically-projecting L5 apical-dendrite activation determines detection; corticocortically-projecting L5 apical activation does not.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-7a17e6b19058"
  ],
  "source_span": "We found that the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice.",
  "study_system": "Awake mouse S1; L5 cell-class-specific transgenic mice; recordings and optogenetic manipulation of apical dendrites in PT vs IT L5 neurons during whisker-detection task",
  "evidence_refs": [
    {
      "ref": "paper:paper-7a17e6b19058"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Transgenic mouse lines selectively labelling subcortically-projecting vs cortico-cortically-projecting L5 pyramidal subclasses; recordings and manipulations of apical-dendrite activity during whisker-detection behavior.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}