Details
- scope
- Awake mouse S1; L5 cell-class-specific transgenic mice; recordings and optogenetic manipulation of apical dendrites in PT vs IT L5 neurons during whisker-detection task
- section_id
- section_04
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
- effect_size
- Subcortically-projecting L5 apical-dendrite activation determines detection; corticocortically-projecting L5 apical activation does not.
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-04-translaminar
- source_kind
- review_finding
- source_path
- evidence/section_04_evidence_package.json
- source_span
- We found that the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice.
- study_system
- Awake mouse S1; L5 cell-class-specific transgenic mice; recordings and optogenetic manipulation of apical dendrites in PT vs IT L5 neurons during whisker-detection task
- section_title
- 4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections
- evidence_summary
- Transgenic mouse lines selectively labelling subcortically-projecting vs cortico-cortically-projecting L5 pyramidal subclasses; recordings and manipulations of apical-dendrite activity during whisker-detection behavior.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- single_study
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-04-translaminar
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- claim_text
Within mouse S1, apical-dendrite activation of subcortically projecting L5 pyramidal neurons (PT-type) almost exclusively accounts for tactile detection performance, while corticocortical L5 neurons contribute negligibly to the perceptual readout.
- raw_fields
{ "n": 0, "doi": "10.1038/s41593-020-0677-8", "claim": "Within mouse S1, apical-dendrite activation of subcortically projecting L5 pyramidal neurons (PT-type) almost exclusively accounts for tactile detection performance, while corticocortical L5 neurons contribute negligibly to the perceptual readout.", "cite_key": "Takahashi2020", "evidence": "Transgenic mouse lines selectively labelling subcortically-projecting vs cortico-cortically-projecting L5 pyramidal subclasses; recordings and manipulations of apical-dendrite activity during whisker-detection behavior.", "effect_size": "Subcortically-projecting L5 apical-dendrite activation determines detection; corticocortically-projecting L5 apical activation does not.", "text_access": "abstract_only", "study_system": "Awake mouse S1; L5 cell-class-specific transgenic mice; recordings and optogenetic manipulation of apical dendrites in PT vs IT L5 neurons during whisker-detection task", "argument_role": "supporting", "replication_status": "single_study", "claim_source_sentence": "We found that the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": "activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli" }- source_refs
[ "paper:paper-7a17e6b19058" ]
- evidence_refs
[ { "ref": "paper:paper-7a17e6b19058" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }