Conventional mouse L5a RSG marker genes are absent from the equivalent rat cell…

Details

scope: mouse and rat granular RSG, snRNA-seq
claim_text: Conventional mouse L5a RSG marker genes are absent from the equivalent rat cell type, meaning Cre-driver lines built on mouse-defined markers may not generalize across rodent species without alternative cross-species markers.
section_id: section_02
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-02-anatomy-primer
source_kind: review_finding
source_path: evidence/section_02_evidence_package.json
source_span: Important for Cre-driver line development, we identify alternative, cross-species genes that can be used to selectively target the cell types of the RSG in both mice and rats.
study_system: mouse and rat granular RSG, snRNA-seq
section_title: 2. Mouse-cortex anatomy primer — areal map, layer structure, projection-class nomenclature (IT / PT / CT), tools available for E→E dissection (paired patch, Cre lines, two-photon-targeted patch, optogenetics, EM reconstruction)
evidence_summary: Comparative snRNA-seq of marker gene expression between mouse and rat RSG cell types.
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-02-anatomy-primer
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (4)

raw_fields

{
  "n": null,
  "doi": "10.1523/jneurosci.2246-24.2025",
  "claim": "Conventional mouse L5a RSG marker genes are absent from the equivalent rat cell type, meaning Cre-driver lines built on mouse-defined markers may not generalize across rodent species without alternative cross-species markers.",
  "cite_key": "Brooks2025b",
  "evidence": "Comparative snRNA-seq of marker gene expression between mouse and rat RSG cell types.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse and rat granular RSG, snRNA-seq",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Important for Cre-driver line development, we identify alternative, cross-species genes that can be used to selectively target the cell types of the RSG in both mice and rats.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-3678866fea0b"
]

evidence_refs

[
  {
    "ref": "paper:paper-3678866fea0b"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

Conventional mouse L5a RSG marker genes are absent from the equivalent rat cell…

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Replication

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