Version history

{
  "scope": "mouse, human, and macaque brain slices",
  "claim_text": "Optimized Patch-seq protocols with automated acquisition and online quality control enable systematic multimodal characterization of neurons across species, with nucleus extraction being critical for transcriptomic success and membrane integrity for morphology success.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.65482",
    "claim": "Optimized Patch-seq protocols with automated acquisition and online quality control enable systematic multimodal characterization of neurons across species, with nucleus extraction being critical for transcriptomic success and membrane integrity for morphology success.",
    "evidence": "Protocol generalizable to different species and brain regions, demonstrated on human and macaque brain slices with publicly available tools and datasets.",
    "effect_size": "systematic multimodal data from human and macaque brain slices",
    "text_access": "fulltext",
    "study_system": "mouse, human, and macaque brain slices",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We recognized the importance of extracting the nucleus for transcriptomic success and maximizing membrane integrity during nucleus extraction for morphology success.",
    "replication_evidence_dois": [
      "10.1126/science.adf6484"
    ],
    "effect_size_source_sentence": "The protocol is generalizable to different species and brain regions, as demonstrated by capturing multimodal data from human and macaque brain slices."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "systematic multimodal data from human and macaque brain slices",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-34387544"
  ],
  "source_span": "We recognized the importance of extracting the nucleus for transcriptomic success and maximizing membrane integrity during nucleus extraction for morphology success.",
  "study_system": "mouse, human, and macaque brain slices",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-34387544"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Protocol generalizable to different species and brain regions, demonstrated on human and macaque brain slices with publicly available tools and datasets.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}