Optogenetic activation of L2/3 horizontal projection neurons in mouse barrel co…

Optogenetic activation of L2/3 horizontal projection neurons in mouse barrel cortex suppresses neighbouring superficial layers while simultaneously activating deeper output layers — a layer-specific competition mechanism set by a depth-dependent E/I ratio.

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  "doi": "10.1038/nature08935",
  "claim": "Optogenetic activation of L2/3 horizontal projection neurons in mouse barrel cortex suppresses neighbouring superficial layers while simultaneously activating deeper output layers — a layer-specific competition mechanism set by a depth-dependent E/I ratio.",
  "cite_key": "Adesnik2010",
  "evidence": "Selective optogenetic activation of horizontal-projecting L2/3 pyramidal neurons in mouse S1 with in vivo recordings across layers.",
  "effect_size": "Suppression of superficial layers, activation of deep layers via depth-dependent E/I balance.",
  "text_access": "abstract_only",
  "study_system": "mouse somatosensory (barrel) cortex; in vivo optogenetic horizontal-circuit activation",
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  "claim_source_sentence": "We found that horizontal projections suppress superficial layers while simultaneously activating deeper cortical output layers. This layer-specific modulation does not result from a spatial separation of excitation and inhibition, but from a layer-specific ratio between these two opposing conductances.",
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We found that horizontal projections suppress superficial layers while simultaneously activating deeper cortical output layers. This layer-specific modulation does not result from a spatial separation of excitation and inhibition, but from a layer-specific ratio between these two opposing conductances.

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