Version history

{
  "scope": "human, TSC patient brain tissue, snRNA-seq",
  "claim_text": "SST+ interneurons in tuberous sclerosis complex show developmental immaturity including abnormal NKCC1/KCC2 ratio and altered GABA receptor subunit expression",
  "raw_fields": {
    "n": 0,
    "doi": "10.1007/s00401-024-02737-7",
    "claim": "SST+ interneurons in tuberous sclerosis complex show developmental immaturity including abnormal NKCC1/KCC2 ratio and altered GABA receptor subunit expression",
    "evidence": "snRNA-seq in TSC patient tissue reveals SST+ as uniquely immature; altered GABRA1 downregulation and GABRA2 upregulation; altered localization in deeper cortical layers",
    "effect_size": "abnormal NKCC1/KCC2 ratio, downregulation of GABRA1, upregulation of GABRA2 in SST+ interneurons",
    "text_access": "fulltext",
    "study_system": "human, TSC patient brain tissue, snRNA-seq",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "markers of immaturity specifically in SST+ interneurons, including an abnormal NKCC1/KCC2 ratio, indicating an imbalance in chloride homeostasis crucial for the postsynaptic consequences of GABAergic signaling",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "this study reveals markers of immaturity specifically in SST+ interneurons, including an abnormal NKCC1/KCC2 ratio, indicating an imbalance in chloride homeostasis crucial for the postsynaptic consequences of GABAergic signaling as well as the downregulation of GABA A receptor subunits, GABRA1 , and upregulation of GABRA2."
  },
  "section_id": "section_03_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "effect_size": "abnormal NKCC1/KCC2 ratio, downregulation of GABRA1, upregulation of GABRA2 in SST+ interneurons",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-9a4f0475d0ca"
  ],
  "source_span": "markers of immaturity specifically in SST+ interneurons, including an abnormal NKCC1/KCC2 ratio, indicating an imbalance in chloride homeostasis crucial for the postsynaptic consequences of GABAergic signaling",
  "study_system": "human, TSC patient brain tissue, snRNA-seq",
  "evidence_refs": [
    {
      "ref": "paper:paper-9a4f0475d0ca"
    }
  ],
  "section_title": "Developmental Origins: MGE Lineage, Specification, and Migration",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "snRNA-seq in TSC patient tissue reveals SST+ as uniquely immature; altered GABRA1 downregulation and GABRA2 upregulation; altered localization in deeper cortical layers",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}