Details
- scope
- human, TSC patient brain tissue, snRNA-seq
- claim_text
- SST+ interneurons in tuberous sclerosis complex show developmental immaturity including abnormal NKCC1/KCC2 ratio and altered GABA receptor subunit expression
- section_id
- section_03_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- effect_size
- abnormal NKCC1/KCC2 ratio, downregulation of GABRA1, upregulation of GABRA2 in SST+ interneurons
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- markers of immaturity specifically in SST+ interneurons, including an abnormal NKCC1/KCC2 ratio, indicating an imbalance in chloride homeostasis crucial for the postsynaptic consequences of GABAergic signaling
- study_system
- human, TSC patient brain tissue, snRNA-seq
- section_title
- Developmental Origins: MGE Lineage, Specification, and Migration
- evidence_summary
- snRNA-seq in TSC patient tissue reveals SST+ as uniquely immature; altered GABRA1 downregulation and GABRA2 upregulation; altered localization in deeper cortical layers
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1007/s00401-024-02737-7", "claim": "SST+ interneurons in tuberous sclerosis complex show developmental immaturity including abnormal NKCC1/KCC2 ratio and altered GABA receptor subunit expression", "evidence": "snRNA-seq in TSC patient tissue reveals SST+ as uniquely immature; altered GABRA1 downregulation and GABRA2 upregulation; altered localization in deeper cortical layers", "effect_size": "abnormal NKCC1/KCC2 ratio, downregulation of GABRA1, upregulation of GABRA2 in SST+ interneurons", "text_access": "fulltext", "study_system": "human, TSC patient brain tissue, snRNA-seq", "replication_status": "replication_unknown", "claim_source_sentence": "markers of immaturity specifically in SST+ interneurons, including an abnormal NKCC1/KCC2 ratio, indicating an imbalance in chloride homeostasis crucial for the postsynaptic consequences of GABAergic signaling", "replication_evidence_dois": [], "effect_size_source_sentence": "this study reveals markers of immaturity specifically in SST+ interneurons, including an abnormal NKCC1/KCC2 ratio, indicating an imbalance in chloride homeostasis crucial for the postsynaptic consequences of GABAergic signaling as well as the downregulation of GABA A receptor subunits, GABRA1 , and upregulation of GABRA2." }- source_refs
[ "paper:paper-9a4f0475d0ca" ]
- evidence_refs
[ { "ref": "paper:paper-9a4f0475d0ca" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }