Version history

{
  "scope": "mouse lateral visual cortex PV+ interneurons and hippocampus-cortex reactivation",
  "claim_text": "In mouse lateral visual cortex, targeted post-training optogenetic perturbation of PV+ inhibitory neurons selectively attenuates cue-specific reactivations and learning, with minimal effect on spontaneous activity and no effect on cue-elicited responses during training, while in controls reactivations are biased toward salient cues and persist for hours after training, with prevalence tracking learning — implicating local PV inhibition as a circuit mechanism for cortical reactivation and memory consolidation.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1126/sciadv.adu9800",
    "claim": "In mouse lateral visual cortex, targeted post-training optogenetic perturbation of PV+ inhibitory neurons selectively attenuates cue-specific reactivations and learning, with minimal effect on spontaneous activity and no effect on cue-elicited responses during training, while in controls reactivations are biased toward salient cues and persist for hours after training, with prevalence tracking learning — implicating local PV inhibition as a circuit mechanism for cortical reactivation and memory consolidation.",
    "cite_key": "Lensj2025",
    "evidence": "Longitudinal two-photon Ca²⁺ imaging plus paired hippocampus-cortex LFP recordings combined with PV-Cre + optogenetic post-training perturbation in mice.",
    "effect_size": "qualitative — PV-driven inhibition gates cortical reactivation and consolidation",
    "text_access": "fulltext",
    "study_system": "mouse lateral visual cortex PV+ interneurons and hippocampus-cortex reactivation",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "targeted manipulation of PV inhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning, with only minute effects on spontaneous activity and no apparent effect on normal function such as visual cue–elicited responses during training",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "targeted manipulation of PV inhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — PV-driven inhibition gates cortical reactivation and consolidation",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-5812d7f5c0e4"
  ],
  "source_span": "targeted manipulation of PV inhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning, with only minute effects on spontaneous activity and no apparent effect on normal function such as visual cue–elicited responses during training",
  "study_system": "mouse lateral visual cortex PV+ interneurons and hippocampus-cortex reactivation",
  "evidence_refs": [
    {
      "ref": "paper:paper-5812d7f5c0e4"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Longitudinal two-photon Ca²⁺ imaging plus paired hippocampus-cortex LFP recordings combined with PV-Cre + optogenetic post-training perturbation in mice.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}