In mouse lateral visual cortex, targeted post-training optogenetic perturbation…

In mouse lateral visual cortex, targeted post-training optogenetic perturbation of PV+ inhibitory neurons selectively attenuates cue-specific reactivations and learning, with minimal effect on spontaneous activity and no effect on cue-elicited responses during training, while in controls reactivations are biased toward salient cues and persist for hours after training, with prevalence tracking learning — implicating local PV inhibition as a circuit mechanism for cortical reactivation and memory consolidation.

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  "n": 0,
  "doi": "10.1126/sciadv.adu9800",
  "claim": "In mouse lateral visual cortex, targeted post-training optogenetic perturbation of PV+ inhibitory neurons selectively attenuates cue-specific reactivations and learning, with minimal effect on spontaneous activity and no effect on cue-elicited responses during training, while in controls reactivations are biased toward salient cues and persist for hours after training, with prevalence tracking learning — implicating local PV inhibition as a circuit mechanism for cortical reactivation and memory consolidation.",
  "cite_key": "Lensj2025",
  "evidence": "Longitudinal two-photon Ca²⁺ imaging plus paired hippocampus-cortex LFP recordings combined with PV-Cre + optogenetic post-training perturbation in mice.",
  "effect_size": "qualitative — PV-driven inhibition gates cortical reactivation and consolidation",
  "text_access": "fulltext",
  "study_system": "mouse lateral visual cortex PV+ interneurons and hippocampus-cortex reactivation",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "targeted manipulation of PV inhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning, with only minute effects on spontaneous activity and no apparent effect on normal function such as visual cue–elicited responses during training",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "targeted manipulation of PV inhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning"
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targeted manipulation of PV inhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning, with only minute effects on spontaneous activity and no apparent effect on normal function such as visual cue–elicited responses during training

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