Version history

{
  "scope": "Developing mouse S1→M1 (in utero electroporation)",
  "claim_text": "Association projections from mouse primary somatosensory cortex L2/3 to primary motor cortex develop as interstitial collaterals of pre-existing callosal axons rather than as independently navigating projections.",
  "raw_fields": {
    "n": null,
    "doi": "10.1093/cercor/bhab153",
    "claim": "Association projections from mouse primary somatosensory cortex L2/3 to primary motor cortex develop as interstitial collaterals of pre-existing callosal axons rather than as independently navigating projections.",
    "cite_key": "Oka2021",
    "evidence": "Sparse in utero electroporation + confocal imaging of flattened/optically-cleared mouse cortices, tracking dual-projection (callosal + association) neurons in S1.",
    "effect_size": ">80% of S1 L2/3 neurons projecting to M1 are callosal-marker positive; association axon extends from a callosal collateral.",
    "text_access": "abstract_only",
    "study_system": "Developing mouse S1→M1 (in utero electroporation)",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "Using the promoter of an established callosal neuron marker gene that was expressed in over 80% of L2/3 neurons in the primary somatosensory cortex (S1) that project to the primary motor cortex (M1), we found that an association projection of a single neuron was the longest among the interstitial collaterals that branched out in L5 from the earlier-extended callosal projection.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Collaterals to M1 elongated primarily within the cortical gray matter with little branching before reaching the target."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": ">80% of S1 L2/3 neurons projecting to M1 are callosal-marker positive; association axon extends from a callosal collateral.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-ed60bfe85054"
  ],
  "source_span": "Using the promoter of an established callosal neuron marker gene that was expressed in over 80% of L2/3 neurons in the primary somatosensory cortex (S1) that project to the primary motor cortex (M1), we found that an association projection of a single neuron was the longest among the interstitial collaterals that branched out in L5 from the earlier-extended callosal projection.",
  "study_system": "Developing mouse S1→M1 (in utero electroporation)",
  "evidence_refs": [
    {
      "ref": "paper:paper-ed60bfe85054"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Sparse in utero electroporation + confocal imaging of flattened/optically-cleared mouse cortices, tracking dual-projection (callosal + association) neurons in S1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}