Association projections from mouse primary somatosensory cortex L2/3 to primary…

{
  "n": null,
  "doi": "10.1093/cercor/bhab153",
  "claim": "Association projections from mouse primary somatosensory cortex L2/3 to primary motor cortex develop as interstitial collaterals of pre-existing callosal axons rather than as independently navigating projections.",
  "cite_key": "Oka2021",
  "evidence": "Sparse in utero electroporation + confocal imaging of flattened/optically-cleared mouse cortices, tracking dual-projection (callosal + association) neurons in S1.",
  "effect_size": ">80% of S1 L2/3 neurons projecting to M1 are callosal-marker positive; association axon extends from a callosal collateral.",
  "text_access": "abstract_only",
  "study_system": "Developing mouse S1→M1 (in utero electroporation)",
  "argument_role": "supporting",
  "replication_status": "single-study",
  "claim_source_sentence": "Using the promoter of an established callosal neuron marker gene that was expressed in over 80% of L2/3 neurons in the primary somatosensory cortex (S1) that project to the primary motor cortex (M1), we found that an association projection of a single neuron was the longest among the interstitial collaterals that branched out in L5 from the earlier-extended callosal projection.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Collaterals to M1 elongated primarily within the cortical gray matter with little branching before reaching the target."
}

[
  "paper:paper-ed60bfe85054"
]

Using the promoter of an established callosal neuron marker gene that was expressed in over 80% of L2/3 neurons in the primary somatosensory cortex (S1) that project to the primary motor cortex (M1), we found that an association projection of a single neuron was the longest among the interstitial collaterals that branched out in L5 from the earlier-extended callosal projection.

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