Version history

{
  "scope": "rat, dopamine-intact GPe, juxtacellular recording with molecular and circuit identification",
  "claim_text": "In dopamine-intact rats, prototypic Nkx2-1/Lhx6 GPe neurons constitute ~67% of GPe and innervate STN, while FoxP2+ arkypallidal neurons constitute ~27% and innervate striatum but not STN, confirming the dichotomy in the absence of pathology.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.4662-14.2015",
    "claim": "In dopamine-intact rats, prototypic Nkx2-1/Lhx6 GPe neurons constitute ~67% of GPe and innervate STN, while FoxP2+ arkypallidal neurons constitute ~27% and innervate striatum but not STN, confirming the dichotomy in the absence of pathology.",
    "cite_key": "Abdi2015",
    "evidence": "",
    "effect_size": "~67% prototypic vs ~27% arkypallidal; arkypallidal target striatum but not STN",
    "text_access": "abstract_only",
    "study_system": "rat, dopamine-intact GPe, juxtacellular recording with molecular and circuit identification",
    "source_cluster_id": "cluster_04",
    "replication_status": "replicated",
    "claim_source_sentence": "Prototypic neurons coexpressed the transcription factors Nkx2-1 and Lhx6, comprised approximately two-thirds of all GPe neurons, and were the major GPe cell type innervating the subthalamic nucleus (STN).",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2012.04.027",
      "10.1523/jneurosci.4672-14.2015",
      "10.1016/j.neuron.2015.03.007"
    ],
    "effect_size_source_sentence": "In contrast, arkypallidal neurons expressed the transcription factor FoxP2, constituted just over one-fourth of GPe neurons, and innervated the striatum but not STN."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json",
  "effect_size": "~67% prototypic vs ~27% arkypallidal; arkypallidal target striatum but not STN",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-83df86143d80"
  ],
  "source_span": "Prototypic neurons coexpressed the transcription factors Nkx2-1 and Lhx6, comprised approximately two-thirds of all GPe neurons, and were the major GPe cell type innervating the subthalamic nucleus (STN).",
  "study_system": "rat, dopamine-intact GPe, juxtacellular recording with molecular and circuit identification",
  "evidence_refs": [
    {
      "ref": "paper:paper-83df86143d80"
    }
  ],
  "section_title": "Pallidal Organization and the Disinhibition Principle",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}