Version history

{
  "scope": "mouse auditory + medial prefrontal cortex; isoflurane anesthesia; in vivo Ca2+ imaging + DREADD",
  "claim_text": "During isoflurane-induced burst suppression in mouse cortex, only PV interneuron manipulation (chemogenetic activation or inhibition) bidirectionally alters pyramidal-cell synchrony (P<0.0001), while SST or VIP manipulation has no effect, indicating VIP cells do not gate burst-suppression synchrony.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.bja.2024.10.052",
    "pmid": "39890488",
    "year": "2025",
    "claim": "During isoflurane-induced burst suppression in mouse cortex, only PV interneuron manipulation (chemogenetic activation or inhibition) bidirectionally alters pyramidal-cell synchrony (P<0.0001), while SST or VIP manipulation has no effect, indicating VIP cells do not gate burst-suppression synchrony.",
    "pmcid": "PMC11947606",
    "title": "Synchronicity of pyramidal neurones in the neocortex dominates isoflurane-induced burst suppression in mice.",
    "authors": "",
    "journal": "",
    "cite_key": "Yin2025",
    "evidence": "EEG + micro-endoscopic Ca2+ imaging in auditory and prefrontal cortex; chemogenetic manipulation of cell-type-specific cortical interneurons.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "Only PV manipulation: P<0.0001 vs no effect of SST/VIP",
    "figure_data": [],
    "text_access": "abstract_only",
    "study_system": "mouse auditory + medial prefrontal cortex; isoflurane anesthesia; in vivo Ca2+ imaging + DREADD",
    "cited_by_count": 8,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 37,
    "claim_source_sentence": "Only activation or inhibition of PV neurones, but not SST or Vip neurones, decreased (P<0.0001) or increased (P<0.0001) isoflurane-induced neuronal synchrony.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Only activation or inhibition of PV neurones, but not SST or Vip neurones, decreased (P<0.0001) or increased (P<0.0001) isoflurane-induced neuronal synchrony."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "Only PV manipulation: P<0.0001 vs no effect of SST/VIP",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-00e6a6ccf6df"
  ],
  "source_span": "Only activation or inhibition of PV neurones, but not SST or Vip neurones, decreased (P<0.0001) or increased (P<0.0001) isoflurane-induced neuronal synchrony.",
  "study_system": "mouse auditory + medial prefrontal cortex; isoflurane anesthesia; in vivo Ca2+ imaging + DREADD",
  "evidence_refs": [
    {
      "ref": "paper:paper-00e6a6ccf6df"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "EEG + micro-endoscopic Ca2+ imaging in auditory and prefrontal cortex; chemogenetic manipulation of cell-type-specific cortical interneurons.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}