During isoflurane-induced burst suppression in mouse cortex, only PV interneuro…

During isoflurane-induced burst suppression in mouse cortex, only PV interneuron manipulation (chemogenetic activation or inhibition) bidirectionally alters pyramidal-cell synchrony (P<0.0001), while SST or VIP manipulation has no effect, indicating VIP cells do not gate burst-suppression synchrony.

{
  "n": null,
  "doi": "10.1016/j.bja.2024.10.052",
  "pmid": "39890488",
  "year": "2025",
  "claim": "During isoflurane-induced burst suppression in mouse cortex, only PV interneuron manipulation (chemogenetic activation or inhibition) bidirectionally alters pyramidal-cell synchrony (P<0.0001), while SST or VIP manipulation has no effect, indicating VIP cells do not gate burst-suppression synchrony.",
  "pmcid": "PMC11947606",
  "title": "Synchronicity of pyramidal neurones in the neocortex dominates isoflurane-induced burst suppression in mice.",
  "authors": "",
  "journal": "",
  "cite_key": "Yin2025",
  "evidence": "EEG + micro-endoscopic Ca2+ imaging in auditory and prefrontal cortex; chemogenetic manipulation of cell-type-specific cortical interneurons.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "Only PV manipulation: P<0.0001 vs no effect of SST/VIP",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "mouse auditory + medial prefrontal cortex; isoflurane anesthesia; in vivo Ca2+ imaging + DREADD",
  "cited_by_count": 8,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 37,
  "claim_source_sentence": "Only activation or inhibition of PV neurones, but not SST or Vip neurones, decreased (P<0.0001) or increased (P<0.0001) isoflurane-induced neuronal synchrony.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Only activation or inhibition of PV neurones, but not SST or Vip neurones, decreased (P<0.0001) or increased (P<0.0001) isoflurane-induced neuronal synchrony."
}

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]

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  }
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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