Version history

{
  "scope": "Mouse ALM, awake; in vivo extracellular recording + photostimulation in memory-guided task",
  "claim_text": "In mouse anterior lateral motor cortex (ALM) during memory-guided movement, recurrent circuits implement feedforward amplification (in the Murphy-Miller / Goldman / Ganguli sense): small-amplitude early-direction signals are amplified into low-dimensional late-direction choice selectivity, explaining paradoxical perturbation responses observed in V1 and motor cortex.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1101/2023.08.04.552026",
    "claim": "In mouse anterior lateral motor cortex (ALM) during memory-guided movement, recurrent circuits implement feedforward amplification (in the Murphy-Miller / Goldman / Ganguli sense): small-amplitude early-direction signals are amplified into low-dimensional late-direction choice selectivity, explaining paradoxical perturbation responses observed in V1 and motor cortex.",
    "cite_key": "Daie2023",
    "evidence": "Influence-mapping analysis of electrophysiological recordings in mouse ALM during memory-guided task; targeted photostimulation tests of activity propagation across early/late directions.",
    "effect_size": "qualitative — neurons selective for one choice can be predicted to influence behavior in opposite direction; sequential activity from early to late directions",
    "text_access": "abstract_only",
    "study_system": "Mouse ALM, awake; in vivo extracellular recording + photostimulation in memory-guided task",
    "argument_role": "supporting",
    "replication_status": "within_lab",
    "claim_source_sentence": "These results were consistent with models in which recurrent circuits produce feedforward amplification (Goldman 2009; Ganguli et al. 2008; Murphy & Miller 2009) so that small amplitude signals along early directions are amplified to produce low-dimensional choice selectivity along the late directions, and behavior.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Targeted photostimulation experiments (Daie et al. 2021b) revealed that activity along the early directions triggered sequential activity along the later directions and caused predictable behavioral biases."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "qualitative — neurons selective for one choice can be predicted to influence behavior in opposite direction; sequential activity from early to late directions",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:b1a3a59e-a093-4a17-a122-e55925015edb"
  ],
  "source_span": "These results were consistent with models in which recurrent circuits produce feedforward amplification (Goldman 2009; Ganguli et al. 2008; Murphy & Miller 2009) so that small amplitude signals along early directions are amplified to produce low-dimensional choice selectivity along the late directions, and behavior.",
  "study_system": "Mouse ALM, awake; in vivo extracellular recording + photostimulation in memory-guided task",
  "evidence_refs": [
    {
      "ref": "paper:b1a3a59e-a093-4a17-a122-e55925015edb"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Influence-mapping analysis of electrophysiological recordings in mouse ALM during memory-guided task; targeted photostimulation tests of activity propagation across early/late directions.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "within_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}