In mouse anterior lateral motor cortex (ALM) during memory-guided movement, rec…

In mouse anterior lateral motor cortex (ALM) during memory-guided movement, recurrent circuits implement feedforward amplification (in the Murphy-Miller / Goldman / Ganguli sense): small-amplitude early-direction signals are amplified into low-dimensional late-direction choice selectivity, explaining paradoxical perturbation responses observed in V1 and motor cortex.

{
  "n": 0,
  "doi": "10.1101/2023.08.04.552026",
  "claim": "In mouse anterior lateral motor cortex (ALM) during memory-guided movement, recurrent circuits implement feedforward amplification (in the Murphy-Miller / Goldman / Ganguli sense): small-amplitude early-direction signals are amplified into low-dimensional late-direction choice selectivity, explaining paradoxical perturbation responses observed in V1 and motor cortex.",
  "cite_key": "Daie2023",
  "evidence": "Influence-mapping analysis of electrophysiological recordings in mouse ALM during memory-guided task; targeted photostimulation tests of activity propagation across early/late directions.",
  "effect_size": "qualitative — neurons selective for one choice can be predicted to influence behavior in opposite direction; sequential activity from early to late directions",
  "text_access": "abstract_only",
  "study_system": "Mouse ALM, awake; in vivo extracellular recording + photostimulation in memory-guided task",
  "argument_role": "supporting",
  "replication_status": "within_lab",
  "claim_source_sentence": "These results were consistent with models in which recurrent circuits produce feedforward amplification (Goldman 2009; Ganguli et al. 2008; Murphy & Miller 2009) so that small amplitude signals along early directions are amplified to produce low-dimensional choice selectivity along the late directions, and behavior.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Targeted photostimulation experiments (Daie et al. 2021b) revealed that activity along the early directions triggered sequential activity along the later directions and caused predictable behavioral biases."
}

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These results were consistent with models in which recurrent circuits produce feedforward amplification (Goldman 2009; Ganguli et al. 2008; Murphy & Miller 2009) so that small amplitude signals along early directions are amplified to produce low-dimensional choice selectivity along the late directions, and behavior.

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