Version history

{
  "scope": "mouse visual cortex; activity-dependent gene programs",
  "claim_text": "Sensory experience drives a VIP-specific transcriptional response — induction of insulin-like growth factor 1 (IGF1) in VIP+ interneurons — which in turn promotes formation of inhibitory synapses *onto* the VIP cells themselves, providing a homeostatic experience-dependent feedback that adjusts disinhibitory drive without altering VIP intrinsic firing.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2018.10.009",
    "claim": "Sensory experience drives a VIP-specific transcriptional response — induction of insulin-like growth factor 1 (IGF1) in VIP+ interneurons — which in turn promotes formation of inhibitory synapses *onto* the VIP cells themselves, providing a homeostatic experience-dependent feedback that adjusts disinhibitory drive without altering VIP intrinsic firing.",
    "title": null,
    "cite_key": "Lim2018",
    "evidence": "Mardinly et al 2016 (cited in Lim review)",
    "effect_size": "qualitative — VIP-specific transcriptional response distinct from PV/SST",
    "text_access": "fulltext",
    "study_system": "mouse visual cortex; activity-dependent gene programs",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 66,
    "claim_source_sentence": "In contrast, neuronal activity induces a completely different transcriptional response in VIP+ interneurons, promoting the formation of inhibitory synapses on these cells.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "qualitative — VIP-specific transcriptional response distinct from PV/SST",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-11e0bb0a904f"
  ],
  "source_span": "In contrast, neuronal activity induces a completely different transcriptional response in VIP+ interneurons, promoting the formation of inhibitory synapses on these cells.",
  "study_system": "mouse visual cortex; activity-dependent gene programs",
  "evidence_refs": [
    {
      "ref": "paper:paper-11e0bb0a904f"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Mardinly et al 2016 (cited in Lim review)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}