- claim_text
Sensory experience drives a VIP-specific transcriptional response — induction of insulin-like growth factor 1 (IGF1) in VIP+ interneurons — which in turn promotes formation of inhibitory synapses *onto* the VIP cells themselves, providing a homeostatic experience-dependent feedback that adjusts disinhibitory drive without altering VIP intrinsic firing.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2018.10.009",
"claim": "Sensory experience drives a VIP-specific transcriptional response — induction of insulin-like growth factor 1 (IGF1) in VIP+ interneurons — which in turn promotes formation of inhibitory synapses *onto* the VIP cells themselves, providing a homeostatic experience-dependent feedback that adjusts disinhibitory drive without altering VIP intrinsic firing.",
"title": null,
"cite_key": "Lim2018",
"evidence": "Mardinly et al 2016 (cited in Lim review)",
"effect_size": "qualitative — VIP-specific transcriptional response distinct from PV/SST",
"text_access": "fulltext",
"study_system": "mouse visual cortex; activity-dependent gene programs",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replication_unknown",
"_source_cluster_index": 66,
"claim_source_sentence": "In contrast, neuronal activity induces a completely different transcriptional response in VIP+ interneurons, promoting the formation of inhibitory synapses on these cells.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons."
}- source_refs
[
"paper:paper-11e0bb0a904f"
]
- evidence_refs
[
{
"ref": "paper:paper-11e0bb0a904f"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}